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The incidence was highest in muscle from patients with peripheral neuropathy, but swellings were present in muscle from patients with motor neuron disease, primary muscle diseases, and some individuals without clinical or histological evidence of neuromuscular disease. The greatest number of swellings in intramuscular nerves was in muscle from patients with chronic inflammatory demyelinating neuropathy. Swellings were spherical or elliptical, 4\u201320 \u03bcm in diameter, 5\u201330 \u03bcm in length, and composed of neurofilaments. Swellings were present only in myelinated axons of intramuscular nerves, proximal to nodes of Ranvier or in internodal regions. Swellings were not associated with axonal degeneration. They were probably not transported. The formation or accumulation of swellings may reflect altered axonal dynamics common to a number of disease processes. \u00a9 1992 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880151111","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:58:31Z","timestamp":1104573511000},"page":"1284-1289","source":"Crossref","is-referenced-by-count":13,"title":["Axonal swellings in human intramuscular nerves"],"prefix":"10.1002","volume":"15","author":[{"given":"Kathy","family":"Alderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120103"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490460025001"},{"key":"e_1_2_1_4_2","volume-title":"Degeneration and Regeneration of the Nervous System","author":"Cajal SRY","year":"1968"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.9.841"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.2.297"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198405000-00004"},{"key":"e_1_2_1_8_2","volume-title":"The Innervation of Muscle","author":"Coers C","year":"1959"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(84)90199-0"},{"key":"e_1_2_1_10_2","first-page":"825","volume-title":"Peripheral Neuropathy","author":"Dyck PJ","year":"1984"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197703000-00002"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198409000-00001"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01159384"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01159385"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490450038004"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196707000-00001"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197605000-00001"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(85)90008-6"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197404000-00006"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.2.183"},{"key":"e_1_2_1_21_2","first-page":"282","article-title":"Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls","volume":"56","author":"Schmidt ML","year":"1987","journal-title":"Lab Invest"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196810000-00008"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(74)90110-5"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197703000-00005"},{"key":"e_1_2_1_25_2","first-page":"163","article-title":"Experimental production of neurofibrillary degeneration. 2. 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