{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T16:22:03Z","timestamp":1698337323816},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4334,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma and IgG obtained from 10 Lambert\u2013Eaton myasthenic syndrome (LES) patients (5 with carcinoma, 5 without associated cancer), 6 healthy subjects, and 1 patient with small\u2010cell lung cancer (SCLC) were examined in their ability to recognize chromaffin cell antigens on Western blots. The pattern of antigen recognition was compared with the magnitude of inhibition of voltage\u2010dependent calcium and sodium currents recorded with the patch\u2010clamp technique from chromaffin cells. Eight of the 11 patients with LES and\/or SCLC recognized plasma membrane proteins and 9 of the patients' IgG interacted with cytoplasmic antigens with no apparent pattern of antigen recognition between patients. Also, there was no obvious band pattern distinguishing patients with LES from those with LES and concurrent SCLC. Eighty percent of the LES patients' antibodies were capable of reducing the calcium current (I<jats:sub>Ca<\/jats:sub>) in chromaffin cells. One of the novel findings of this study is that 30% of the patients had produced antibodies which were able to inhibit both calcium and sodium currents (I<jats:sub>Na<\/jats:sub>). The heterogeneous response of the IgG on the Western blots does not appear to correlate with the efficacy of reducing the inward currents. \u00a9 1992 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880151206","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:58:38Z","timestamp":1104573518000},"page":"1325-1333","source":"Crossref","is-referenced-by-count":8,"title":["Lambert\u2013Eaton syndrome: Antigen\u2013antibody interaction and calcium current inhibition in chromaffin cells"],"prefix":"10.1002","volume":"15","author":[{"given":"Michael P.","family":"Viglione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl E.","family":"Creutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong I.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.9.1391"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb07394.x"},{"key":"e_1_2_1_4_2","unstructured":"BlandinoJKW KimYI:Lambert\u2010Eaton syndrome IgG reacts with dihydropyridine\u2010sensitive slowly\u2010inactivating (L\u2010type) calcium channels in bovine adrenal chromaffin cells (abstract). The New York Academy of Sciences. Meeting on myasthenia gravis and related disorders: experimental and clinical aspects. Washington DC April 12\u201015 1992."},{"key":"e_1_2_1_5_2","first-page":"310","article-title":"Occurrence of antineuronal antibody without encephalomyelitis in a patient with paraneoplastic Lambert\u2010Eaton syndrome","volume":"30","author":"Brashear HR","year":"1991","journal-title":"Ann Neurol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018614"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018615"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2459775"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(88)90058-6"},{"key":"e_1_2_1_10_2","first-page":"14664","article-title":"Characterization of the chromobindins","volume":"258","author":"Creutz CE","year":"1983","journal-title":"J Biol Chem"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9598-1_3"},{"key":"e_1_2_1_12_2","first-page":"4719","article-title":"Antagonism of voltage\u2010gated calcium channels in small cell carcinomas of patients with and without Lambert\u2010Eaton myasthenic syndrome by autoantibodies, \u03c9\u2010conotoxin and adenosine","volume":"48","author":"De Aizpurua HJ","year":"1988","journal-title":"Canc Res"},{"key":"e_1_2_1_13_2","first-page":"689","article-title":"Detailed analysis of neuromuscular transmission in a patient with the myasthenic syndrome sometimes associated with bronchogenic carcinoma","volume":"43","author":"Elmqvist D","year":"1968","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050905"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220203"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00214792"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656997"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1956.tb14351.x"},{"key":"e_1_2_1_19_2","first-page":"1159","article-title":"\u201cN\u201d\u2010 and \u201cL\u201d\u2010like calcium currents in lung cancer cells are blocked by Lambert\u2010Eaton IgG","volume":"17","author":"Hulsizer SC","year":"1991","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb13323.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1016\/S0021-9258(18)49986-3","article-title":"Structural characterization of the dihydropyridine\u2010sensitive calcium \u03b12\u2010subunit and the associated \u03b4 peptides","volume":"266","author":"Jay SD","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_1_22_2","first-page":"245P","article-title":"Action of Lambert\u2010Eaton syndrome antibodies on voltage\u2010dependent calcium currents and exocytosis in human small\u2010cell lung cancer cells and bovine adrenal chromaffin cells","volume":"446","author":"Kim J","year":"1992","journal-title":"J Physiol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080213"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090608"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2447652"},{"key":"e_1_2_1_26_2","unstructured":"KimYI BlandinoJKW O'ShaughnessyTJ:Inhibitory action of Lambert\u2010Eaton syndrome IgG on N\u2010 and L\u2010type calcium currents in a thyroid C\u2010cell line (abstract). The New York Academy of Sciences. Meeting on myasthenia gravis and related disorders: experimental and clinical aspects. Washington DC April 12\u201015 1992."},{"key":"e_1_2_1_27_2","first-page":"362","volume-title":"Myasthenia Gravis","author":"Lambert EH","year":"1961"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014943"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65705-X"},{"key":"e_1_2_1_30_2","first-page":"S21","article-title":"Autoimmunity in the Lambert\u2010Eaton myasthenic syndrome","volume":"5","author":"Lennon VA","year":"1982","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.1016\/S0021-9258(18)47507-2","article-title":"Structural characterization of the 1,4\u2010dihydropyridine receptor of the voltage\u2010dependent Ca2+ channel from rabbit skeletal muscle","volume":"262","author":"Leung AT","year":"1987","journal-title":"J Biol Chem"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(85)90046-3"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"9854","DOI":"10.1016\/S0021-9258(19)83595-0","article-title":"Isolation of a protein from the plasma membrane of adrenal medulla which binds to secretory vesicles","volume":"254","author":"Meyer DI","year":"1979","journal-title":"J Biol Chem"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.3.577"},{"key":"e_1_2_1_35_2","first-page":"5901","article-title":"Voltage\u2010dependent ion channels in small\u2010cell lung cancer cells","volume":"49","author":"Pancrazio JJ","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp017945"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/317737a0"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2458625"},{"key":"e_1_2_1_39_2","unstructured":"ViglioneMP KimSJ KimYI:Lambert\u2010Eaton syndrome IgG inhibits dihydropyridine\u2010sensitive slowly\u2010inactivating (L\u2010type) calcium currents in small\u2010cell lung cancer cells (abstract). 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