{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T09:57:34Z","timestamp":1760781454937},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4183,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate axonal function in a model of early motor neuron disease, we examined fast and slow components of anterograde axonal transport in the less\u2010affected hindlimb motor neurons of wobbler mice. To study the fast component (FC), we injected tritiated amino acids into the lumbar spinal cord and retrieved the sciatic nerve after 2 or 3 h. The transport distance was the extent of the plateau of labeling; regression analysis indicated that FC was 25% slower in wobbler mice than in unaffected littermates (<jats:italic>P<\/jats:italic> &lt; 0.01). To study slow component (SC), [<jats:sup>35<\/jats:sup>S] methionine was injected. Transport distances were to the peaks of labeling for structural proteins after 2 or 3 weeks. Rates for each subcomponent (SCa and SCb) were unaffected by wobbler disease. Because the rate of retrograde FC is also unaffected (Mitsumoto et al., <jats:italic>Muscle &amp; Nerve<\/jats:italic> 13:121\u2013126, 1990), we conclude that wobbler disease specifically retards anterograde FC in less\u2010affected hindlimb motor neurons, whereas all components of axonal transport are retarded in forelimb motor neurons. \u00a9 1993 John Wiley &amp; Soncs, Inc.<\/jats:p>","DOI":"10.1002\/mus.880160517","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:10:31Z","timestamp":1104567031000},"page":"542-547","source":"Crossref","is-referenced-by-count":17,"title":["Retardation of fast axonal transport in wobbler mice"],"prefix":"10.1002","volume":"16","author":[{"given":"Hiroshi","family":"Mitsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozo","family":"Kurahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane M.","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irvine G.","family":"McQuarrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"147","volume-title":"Statistical Methods in Medical Research","author":"Armitage P","year":"1971"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197501000-00002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.2.247"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140304"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.5.738"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.31.6.535"},{"key":"e_1_2_1_8_2","first-page":"53","article-title":"Hereditary progressive neurogenic muscular atrophy in the mouse","volume":"183","author":"Duchen LW","year":"1966","journal-title":"J Physiol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503143121110"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1980.60.4.1167"},{"key":"e_1_2_1_11_2","first-page":"33","volume-title":"Amyotrophic Lateral Sclerosis","author":"Griffin JW","year":"1976"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230103"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.93.3.568"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.99.1.212s"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1523\/JNEUROSCI.05-12-03135.1985","article-title":"The neuronal endomembrane system. III. The origins of the axoplasmic reticulum and discrete axonal cisternae at the axon hillock","volume":"5","author":"Lindsey JD","year":"1985","journal-title":"J Neurosci"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)91116-2"},{"key":"e_1_2_1_17_2","first-page":"29","volume-title":"Neural Regeneration and Transplantation","author":"McQuarrie IG","year":"1989"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1523\/JNEUROSCI.06-06-01593.1986","article-title":"Diversity in the axonal transport of structural proteins: major differences between optic and spinal axons in the rat","volume":"6","author":"McQuarrie IG","year":"1986","journal-title":"J Neurosci"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880080109"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.4.811"},{"key":"e_1_2_1_21_2","first-page":"126","volume-title":"Current Trends in Neuroscience","author":"Mitsumoto H","year":"1985"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190108"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130206"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.2.497"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(80)90241-1"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880040509"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp010051"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01205226"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480200204"},{"key":"e_1_2_1_30_2","first-page":"92","volume-title":"Experimental and Clinical Neurotoxicology","author":"Spencer PS","year":"1980"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.14.030191.000423"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880160517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880160517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T23:54:36Z","timestamp":1698191676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880160517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1002\/mus.880160517"],"URL":"https:\/\/doi.org\/10.1002\/mus.880160517","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]}}}