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Hybrids were formed by the fusion of normal (from human and mouse) and G6PD\u2010deficient myoblasts (from the patients). These hybrids contained a high level of G6PD activity. Hoechst staining permitted to confirm that the enzymatic activity was not restrained to a domain near the competent nuclei. These results suggest that myoblast transplantation could be used to restore normal enzymatic activity in metabolic myopathies.<\/jats:p>","DOI":"10.1002\/mus.880160604","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:13:23Z","timestamp":1104567203000},"page":"594-600","source":"Crossref","is-referenced-by-count":0,"title":["Muscle glucose\u20106\u2010phosphate dehydrogenase deficiency: Restoration of enzymatic activity in hybrid myotubes"],"prefix":"10.1002","volume":"16","author":[{"given":"Giovanni","family":"Meola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques P.","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Sansone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rotondo,","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Radice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nereo","family":"Bresolin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Huard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Scarlato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"851","volume-title":"Cellular and Molecular Biology of Muscle Development","author":"Blau HM","year":"1989"},{"key":"e_1_2_1_3_2","first-page":"167","volume-title":"Localization of muscle gene products in nuclear domains: does this constitute a problem for myoblast transfer therapy","author":"Blau HM","year":"1990"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.9.5623"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314498"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01538965"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(83)80018-4"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/356435a0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880140213"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150504"},{"key":"e_1_2_1_11_2","first-page":"27","article-title":"Dystrophin is expressed in mdx skeletal muscle fibers after normal myoblast implantation","volume":"134","author":"Karpati G","year":"1989","journal-title":"Am J Pathol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/39.1.1701185"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91628-N"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000112240"},{"key":"e_1_2_1_15_2","first-page":"1012","volume-title":"Mendelian Inheritance in Man","author":"McKusic VA","year":"1983"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314426"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00718013"},{"key":"e_1_2_1_18_2","article-title":"Early and persistent successful functional innervation in human muscle co\u2010cultured with foetal mouse spinal cord","volume":"229","author":"Meola G","year":"1989","journal-title":"Eur J Neurol Sci"},{"key":"e_1_2_1_19_2","first-page":"219","article-title":"Growth and differentiation of myogenic clones from adult human muscle cell cultures","volume":"35","author":"Meola G","year":"1991","journal-title":"Eur J Bas Appl Histochem"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02337773"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/273306a0"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880140302"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.1.124"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/337570a0"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90924-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5171"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90978-8"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880070908"}],"container-title":["Muscle &amp; 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