{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:54:23Z","timestamp":1761393263327},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4152,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased titers of anti\u2010GM1 antibodies have been associated with motor neuron disease and motor neuropathy with or without conduction block. To investigate the pathogenetic role of anti\u2010GM1 antibodies we injected into rat tibial nerves sera from patients with multifocal motor neuropathy and conduction block (MMN) or progressive spinal muscular atrophy (PMA), both presenting anti\u2010GM1 antibodies. Sera of patients with MMN produced reduction of amplitude and dispersion of compound muscle action potential from proximal stimulation. Morphometry revealed demyelination in 6.2% of fibers. Sera of patients with PMA did not produce clear\u2010cut electrophysiological or morphological changes. Differential effects of sera from patients presenting high\u2010titer anti\u2010GM1 antibodies, but with distinct clinical syndromes, might depend on differences in anti\u2010GM1 antibody affinity, valency, or ability to fix complement. Alternatively, circulating factors other than, or in addition to, anti\u2010GM1 antibodies present in sera of patients with MMN, but not of PMA patients, might be responsible for conduction abnormalities and reproduce them after passive transfer. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880160606","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:13:23Z","timestamp":1104567203000},"page":"610-615","source":"Crossref","is-referenced-by-count":89,"title":["Conduction abnormalities induced by sera of patients with multifocal motor neuropathy and anti\u2010GM1 antibodies"],"prefix":"10.1002","volume":"16","author":[{"given":"Antonino","family":"Uncini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Corbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Lugaresi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Latov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"issue":"3","key":"e_1_2_1_2_2","first-page":"334","article-title":"Characterization of the antigens for anti\u2010GM1 and Gal(\u03b2 1\u20103) GalNAc antibodies at the nodes of Ranvier in peripheral nerve","volume":"42","author":"Corbo M","year":"1992","journal-title":"Neurology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300312"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1212\/WNL.37.2.242","article-title":"Experimental demyelination of nerve induced by serum of patients with neuropathy and anti\u2010MAG IgM M\u2010protein","volume":"37","author":"Hays AP","year":"1987","journal-title":"Neurology"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.1.118"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.497"},{"key":"e_1_2_1_7_2","first-page":"301","article-title":"Peripheral neuropathy and anti\u2010MAG antibodies","volume":"3","author":"Latov N","year":"1988","journal-title":"Crit Rev Neurobiol"},{"key":"e_1_2_1_8_2","first-page":"559","volume-title":"Peripheral Neuropathy","author":"Low PA","year":"1984"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/86.3.501"},{"key":"e_1_2_1_10_2","first-page":"579","volume-title":"Peripheral Neuropathy","author":"Olsson Y","year":"1984"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880110203"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270314"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240113"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.3.357"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280206"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.7.1067"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280312"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310407"},{"key":"e_1_2_1_19_2","first-page":"17","article-title":"Syndrome de Guillain\u2013Barr\u00e9. Effets \u00e9lectrophysiologiques et morphologiques dus\u00e9rum humain introduit dans 'espace endoneural du nerf sciatique du rat. R\u00e9sultats pr\u00e9liminaires","volume":"138","author":"Sumner A","year":"1982","journal-title":"Rev Neurol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110506"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00249394"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880160606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880160606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T15:51:54Z","timestamp":1698249114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880160606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["10.1002\/mus.880160606"],"URL":"https:\/\/doi.org\/10.1002\/mus.880160606","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}