{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:11:42Z","timestamp":1781921502561,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4060,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although conduction block indicates dysfunction of peripheral nerve, itmay occur in patients with clinically typical motor neuron disease. There are no universally accepted criteria to identify conduction block, so diagnosis may be difficult. In some peripheral neuropathies, conduction block persists over long periods of time. If conduction block persists in motor neuron disease, then a more reproducible means for identification would be available. We repeatedly studied 9 patients with different forms of motor neuron diseases; conduction block was suspected because of excessive loss of the amplitude of motor evoked responses between distal and proximal stimulation sites. Five showed persistent amplitude loss at intervals between 12 and 36 months. All had focal loss of amplitude and area across a specific segment; all were men; none had definite upper motor neuron signs, 2 had probable and 3 had no upper motor neuron signs; 1 had IgM paraproteinemia, one elevated anti\u2010GM<jats:sub>1<\/jats:sub> titers; the duration of symptoms spanned 4\u201313 years. Four patients had transient loss of amplitude that was not reproduced in intervals between 3 and 13 months. None had focal loss of both amplitude and area; 2 were men; all had definite upper motor neuron signs and none had symptoms for more than 3\u201313 months; and none had immunological abnormalities. Thus, patients with persistent amplitude loss fulfill other criteria for conduction block, have prolonged survival but otherwise have clinical syndromes indistinguishable from ALS, except that definite upper motor neuron signs seem to be exceptional. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880160903","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:16:13Z","timestamp":1104567373000},"page":"896-903","source":"Crossref","is-referenced-by-count":25,"title":["Persistent and transient \u201cconduction block\u201d in motor neuron diseases"],"prefix":"10.1002","volume":"16","author":[{"given":"Dale J.","family":"Lange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Trojaborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Drake","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"215","article-title":"Multifocal polyneuropathy with conduction blockage. A new subset of inflammatory polyneuropathies","volume":"93","author":"Alvarez\u2010Vadillo E","year":"1989","journal-title":"Mec Clin (Barcelona)"},{"key":"e_1_2_1_3_2","first-page":"192","article-title":"Neuropathy with onion bulb formations and pure motor manifestations","volume":"16","author":"Auer RN","year":"1989","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.33.3.338"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.9.1260"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880140913"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.1.118"},{"key":"e_1_2_1_8_2","first-page":"3","volume-title":"Merritt's Textbook of Neurology","author":"Lange DJ","year":"1991"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.497"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1953.02320260029002"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.9.958"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.11.1639"},{"issue":"1","key":"e_1_2_1_13_2","first-page":"260","article-title":"Patterns of conduction block motor neuropathy: a review of 18 patients (abstract)","volume":"41","author":"Moulonguet A","year":"1991","journal-title":"Neurology"},{"key":"e_1_2_1_14_2","first-page":"15","volume-title":"Human Motor Neuron Diseases","author":"Mulder DW","year":"1972"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880110203"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270314"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240113"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280206"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000116045"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(87)90006-X"},{"key":"e_1_2_1_21_2","first-page":"1056","article-title":"Multifocal neuropathy with persistent conduction blocks (letter)","volume":"15","author":"Magistris M","year":"1992","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_22_2","first-page":"1","volume-title":"Human Motor Neuron Diseases","author":"Rowland LP","year":"1972"},{"key":"e_1_2_1_23_2","first-page":"183","article-title":"Polyclonal IgM anti\u2010GD1b antibody activity in motor neuron disease variant","volume":"40","author":"Salazar\u2010Grueso EF","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280312"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180302"},{"issue":"1","key":"e_1_2_1_26_2","first-page":"182","article-title":"Conduction block and other abnormalities of nerve conduction in motor neuron disease: a review of 110 patients","volume":"40","author":"Trojaborg W","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_1_27_2","first-page":"41","volume-title":"Handbook of Clinical Neurology. Neuropathies","author":"Waxman SG","year":"1987"},{"issue":"1","key":"e_1_2_1_28_2","first-page":"260","article-title":"Motor nerve conduction abnormalities in amyotrophic lateral sclerosis (ALS) (abstract)","volume":"41","author":"Wirquin I","year":"1991","journal-title":"Neurology"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.4.595"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520360022005"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880160903","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880160903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T09:54:27Z","timestamp":1698227667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880160903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/mus.880160903"],"URL":"https:\/\/doi.org\/10.1002\/mus.880160903","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}