{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:12:46Z","timestamp":1763035966513},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4060,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To explore the relationship between hereditary motor and sensory neuropathy (HMSN) and movement disorders, we examined 7 patients with HMSN referred to our Movement Disorders Clinic and surveyed members of the Charcot\u2010Marie\u2010Tooth association. The following movement disorders were observed in the index patients: postural tremor in 6, rest tremor in 3, and Parkinsonism and dystonia in 2. Tremor, present in 40% of the 201 patients who responded to the survey, was first noted at a mean age of 36 years, and mostly involved the hands. Family history of tremor was more frequent in the tremor group (<jats:italic>P<\/jats:italic> &gt; 0.005), which also had a significantly worse writing score than the nontremor group (<jats:italic>P<\/jats:italic> &gt; 0.001). The overlap in clinical features between HMSN\u2010associated tremor and essential tremor (ET), the high frequency of family history of tremor, and the lack of a relationship between the severity of tremor and of peripheral neuropathy suggest that the tremor in HMSN is pathogenically related to ET. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880160904","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:16:13Z","timestamp":1104567373000},"page":"904-910","source":"Crossref","is-referenced-by-count":55,"title":["Hereditary motor\u2013sensory neuropathy and movement disorders"],"prefix":"10.1002","volume":"16","author":[{"given":"Francisco E. 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