{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T14:11:49Z","timestamp":1698329509629},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":4060,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excitability of rat dorsal root axons were studied 3 weeks after injuryto the sciatic nerve. Whole nerve recordings were obtained from injured andcontrol nerves in a sucrose gap chamber. Constant current depolarization pulses (30\u2013200 ms) applied approximately 50% above the stimulus strength required for maximal amplitude compound action potentials (CAPs) evoked burst of action potentials in the dorsal root which displayed spike adaptation. The depolarization\u2010induced burst response of the dorsal roots was greatly reduced after crush or transection of the sciatic nerve. However, application of the potassium channel blocker, tetraethylammonium (TEA), restored the burst discharge in injured dorsal root axons. Brief tetanic stimulation of the dorsal root also induced an afterhyperpolarization (AHP) that was twice as large in the transection group as compared to the control group, and which was blocked by TEA. There were no changes seen in the amplitude of the compound action potential, frequency\u2010following characteristics, refractory properties, or 4\u2010AP sensitivity in the dorsal roots after peripheral nerve injury. These results suggest that there is enhanced spike adaptation that occurs at the same time as an increase in the sensitivity to the potassium channel blocker, TEA, in axon regions proximal to the site of nerve injury and have implications for the pathophysiology of nerve injury. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880160912","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:16:13Z","timestamp":1104567373000},"page":"958-963","source":"Crossref","is-referenced-by-count":3,"title":["Increased spike\u2010frequency adaptation and tea sensitivity in dorsal root fibers after sciatic nerve injury"],"prefix":"10.1002","volume":"16","author":[{"given":"David A.","family":"Utzschneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Bhisitkhul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery D.","family":"Kocsis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016395"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(05)80017-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1152\/jn.1991.66.3.719","article-title":"A voltage\u2010 and time\u2010dependent rectification in rat dorsal spinal root axons","volume":"66","author":"Birch BD","year":"1991","journal-title":"J Neurophys"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(87)90201-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90089-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011944"},{"key":"e_1_2_1_8_2","first-page":"63","volume-title":"Textbook of Pain","author":"Devor M","year":"1989"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/276075a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.6.1733"},{"key":"e_1_2_1_11_2","first-page":"82","volume-title":"Peripheral NeuropathyS","author":"Dyck PJ","year":"1984"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1988.60.6.2168"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp017940"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880140707"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1943.sp004002"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01625187"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90920-3"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/jn.1992.67.1.125","article-title":"Excitation of cutaneous sensory nerve endings in the rat by 4\u2010aminopyridine and tetraethylammonium","volume":"67","author":"Kirchoff C","year":"1992","journal-title":"J Neurophysiol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1982.0095"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/304640a0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90296-5"},{"key":"e_1_2_1_22_2","first-page":"1067","article-title":"Implications of the failure of nerve resection and graft to cure chronic pain produced by nerve lesions","volume":"44","author":"Noordenbos W","year":"1991","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1982.0042"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/315498a0"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(90)90039-J"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90170-C"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90164-1"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/248740a0"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/355075a0"}],"container-title":["Muscle &amp; 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