{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:38:35Z","timestamp":1775975915781,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3999,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic sclerosis (scleroderma) is thought to be the least likely of the collagen vascular disorders to cause nervous system damage. We evaluated the peripheral neuromuscular manifestations in 32 patients with scleroderma. A clinically defined peripheral nervous system (PNS) lesion was manifest in 5 of 32 patients (16%), including 2 patients with trigeminal neuropathy and single cases of polyneuropathy, brachial plexopathy, and lumbosacral radiculopathy. Neurophysiological studies suggested subclinical PNS involvement in 6 additional patients (3 with distal axonal polyneuropathy, 1 with probable myopathy and superimposed polyneuropathy, 1 with trigeminal neuropathy, and 1 with focal ulnar neuropathy). Even though subjective muscular complaints were numerous (16 patients, 50%), a defined primary muscular disease could be demonstrated only in 5 patients (16%). Our results indicate that peripheral neuropathy in scleroderma is not as uncommon as previously estimated. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880161110","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T10:40:50Z","timestamp":1104576050000},"page":"1204-1212","source":"Crossref","is-referenced-by-count":70,"title":["Peripheral neuromuscular manifestations in systemic sclerosis (scleroderma)"],"prefix":"10.1002","volume":"16","author":[{"given":"Aki","family":"Hietaharju","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satu","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Kalimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja","family":"Hietarinta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/29.1.21"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.21.6.609"},{"key":"e_1_2_1_4_2","first-page":"378","article-title":"Carpal tunnel syndrome as the initial manifestation of scleroderma","volume":"13","author":"Barr WG","year":"1988","journal-title":"J Hand Surg"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.27.4.367"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90747-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.12.1633-a"},{"key":"e_1_2_1_8_2","first-page":"465","volume-title":"Handbook of Clinical Neurology. Neuropathies","author":"Bruyn RPM","year":"1987"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210111"},{"key":"e_1_2_1_10_2","first-page":"2027","volume-title":"Peripheral Neuropathy","author":"Conn DL","year":"1984"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685970"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.4.861"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(91)90040-Z"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90926-3"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480200032003"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250110"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1961.00450090047007"},{"key":"e_1_2_1_18_2","first-page":"204","article-title":"Polychrome stain for differentiating precollagen from collagen","volume":"38","author":"Herovici C","year":"1963","journal-title":"Stain Technol"},{"key":"e_1_2_1_19_2","article-title":"Central nervous system involvement and psychiatric manifestations in systemic sclerosis (scleroderma): clinical and neurophysiological evaluation","author":"Hietaharju A","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5188.1781"},{"key":"e_1_2_1_21_2","first-page":"307","volume-title":"Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice","author":"Kimura J","year":"1989"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.7.542"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(88)90030-3"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.6.1463"},{"key":"e_1_2_1_25_2","first-page":"480","article-title":"Neurological manifestations in systemic sclerosis (scleroderma)","volume":"11","author":"Lee P","year":"1984","journal-title":"J Rheumatol"},{"key":"e_1_2_1_26_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis (editorial)","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_1_27_2","first-page":"33","article-title":"The spectrum of scleroderma","volume":"24","author":"Le Roy EC","year":"1989","journal-title":"Hosp Pract"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685374"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.2.533"},{"key":"e_1_2_1_30_2","first-page":"1118","volume-title":"Arthritis and Allied Conditions","author":"Medsger TA","year":"1989"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780110405"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.3.390"},{"key":"e_1_2_1_33_2","first-page":"942","article-title":"Vasculitis in systemic sclerosis: association with Sj\u00f6gren's syndrome and the CREST syndrome variant","volume":"14","author":"Oddis CV","year":"1987","journal-title":"J Rheumatol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009746009165023"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150502"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.6.808"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1001\/archderm.1966.01600250026003","article-title":"Carpal tunnel syndrome in dermatomyositis and scleroderma","volume":"94","author":"Quinones CA","year":"1966","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195401000-00013"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1001\/archinte.1990.00390230098013","article-title":"Muscle involvement in the scleroderma syndromes","volume":"150","author":"Ringel RA","year":"1990","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_40_2","first-page":"16","volume-title":"Systemic Sclerosis (Scleroderma). Current Topics in Rheumatology","author":"Rodnan GP","year":"1985"},{"key":"e_1_2_1_41_2","first-page":"241","volume-title":"Systemic Sclerosis: Scleroderma","author":"Russell ML","year":"1988"},{"key":"e_1_2_1_42_2","first-page":"661","article-title":"Peripheral nerve dysfunction in scleroderma","volume":"80","author":"Schady W","year":"1991","journal-title":"QJ Med"},{"key":"e_1_2_1_43_2","first-page":"684","article-title":"Scleroderma associated with neurological and psychogenic symptoms\u2014with four case reports","volume":"40","author":"Senseman LA","year":"1967","journal-title":"Rhode Island Med J"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.11.957"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198003000-00006"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580150005001"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00242818"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880161110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880161110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880161110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T11:04:00Z","timestamp":1698231840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880161110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1002\/mus.880161110"],"URL":"https:\/\/doi.org\/10.1002\/mus.880161110","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}