{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:05:13Z","timestamp":1760954713844},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3938,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multifocal motor neuropathy (MMN) is a disorder with a highly characteristic clinical picture and one which is defined by a specific electrodiagnostic abnormality, namely, multifocal conduction block which is confined to motor axons. Sensory axons which traverse segments of severe or even complete motor conduction block conduct normally. A proportion of patients with MMN also have elevated levels of antibodies to GM<jats:sub>1<\/jats:sub> ganglioside. However, about one half of MMN patients lack elevated levels of these antibodies and many others have only modest elevations, to a degree often seen in other neurological and even non\u2010neurological disorders. Furthermore, clinical and electrophysiological improvement of MMN in response to treatment with high dose intravenous immunoglobulin is achieved in the absence of any change in antiglycolipid levels. Injection of serum from patients with MMN and elevated GM<jats:sub>1<\/jats:sub> antibody levels produces demyelination in recipient rat nerves, suggesting a pathogenetic role for these antibodies in demyelination. However, sera of patients with identical antibody liters in other motor system diseases produced no demyelination, suggesting that the demyelinating factor resides in some other serum fraction. At present, there is insufficient evidence to support the contention that these antibodies play a critical pathogenetic role in MMN. Until more evidence is available it is important to define MMN on the basis of a characteristic clinical picture and a unique electrodiagnostic abnormality rather than on a pattern of serum antibodies. \u00a9 1994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880170114","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:23:10Z","timestamp":1104567790000},"page":"97-99","source":"Crossref","is-referenced-by-count":43,"title":["Antiganglioside antibodies do not necessarily play a role in multifocal motor neuropathy"],"prefix":"10.1002","volume":"17","author":[{"given":"Gareth John Glyn","family":"Parry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.4049\/jimmunol.132.4.1793","article-title":"Antibodies to glycosphingolipids in patients with multiple Sclerosis and SLE","volume":"132","author":"Endo T","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300312"},{"key":"e_1_2_1_4_2","first-page":"243","article-title":"Antibodies to glycolipids in Guillain\u2010Barre syndrome and chronic inflammatory demyelinating polyneuropathy (abstract)","volume":"28","author":"Ilyas A","year":"1990","journal-title":"Ann Neurol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.506"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330204"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141014"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.497"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.9.958"},{"key":"e_1_2_1_10_2","unstructured":"MeucciN Nobile\u2010OrazioE CarpoM BarbieriS ScarlatoG: Anti\u2010GM1 antibodies in multifocal motor neuropathy: effect of intravenous immunoglobulin therapy. Twenty\u2010eighth Annual Meeting of the Italian Neuropathological Association 1992."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.11.1747"},{"issue":"3","key":"e_1_2_1_12_2","first-page":"179","article-title":"Prednisone treatment of multifocal predominantly\u2010motor neuropathy (abstract)","volume":"42","author":"Olney RK","year":"1992","journal-title":"Neurology"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30203-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240113"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.9.1457"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270314"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310407"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270710"},{"issue":"3","key":"e_1_2_1_19_2","first-page":"179","article-title":"Passive transfer of conduction abnormalities with serum from patients with anti\u2010GM1 antibodies and neuropathy (abstract)","volume":"42","author":"Uncini A","year":"1992","journal-title":"Neurology"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.12.1900"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880170114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880170114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T06:38:30Z","timestamp":1698129510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880170114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/mus.880170114"],"URL":"https:\/\/doi.org\/10.1002\/mus.880170114","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}