{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:39:33Z","timestamp":1785577173616,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3879,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although exertional myopathies are commonly recognized in horses, specific etiologies have not been identified. This is the first report in the horse of a deficiency of Complex I respiratory chain enzyme associated with profound exercise intolerance. Physical examination, routine blood tests, endoscopy, and ultrasonograms of the heart and iliac arteries were unremarkable. With slow, incremental exercise (speeds 1.5\u20137 m\/s), the Arabian mare showed a marked lactic acidosis, increased mixed venous PVO<jats:sub>2<\/jats:sub>, and little change in oxygen consumption. Muscle biopsies contained large accumulations of mitochondria with bizarre cristae formations. Biochemical analyses revealed a very low activity of the first enzyme complex in the mitochondrial respiratory chain (NADH CoQ reductase). The exercise intolerance and muscle stiffness in this horse were attributed to a profound lactic acidosis resulting from impaired oxidative energy metabolism during exercise. \u00a9 1994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880170308","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:32:51Z","timestamp":1104568371000},"page":"305-312","source":"Crossref","is-referenced-by-count":39,"title":["Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse"],"prefix":"10.1002","volume":"17","author":[{"given":"Stephanie J.","family":"Valberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"George H.","family":"Cardinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric K.","family":"Birks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Chomyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"DiMauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"S726","article-title":"Equine exertional rhabdomyolysis","volume":"6","author":"Arighi M","year":"1984","journal-title":"Comp Cont Educ"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90618-9"},{"key":"e_1_2_1_4_2","first-page":"179","volume-title":"Equine exercise physiology","author":"Birks EK","year":"1991"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.6.802"},{"key":"e_1_2_1_6_2","series-title":"Ann NY Acad Sci","first-page":"290","author":"Cardinet GH","year":"1979"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/314592a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3764430"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.11.4.2236"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6262916"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130104"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1980.tb03420.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/348651a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a110103"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114135"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115422"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(77)80048-8"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1982.tb02389.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.2.862"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(80)90013-3"},{"key":"e_1_2_1_21_2","first-page":"303","article-title":"Acid\u2010base and electrolyte alterations in horses with exertional rhabdomyolysis","volume":"180","author":"Koterba A","year":"1982","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/BF03547460","article-title":"Fibre composition, enzyme activities and metabolites and electrolytes in muscle of standardbred horses","volume":"15","author":"Lindholm A","year":"1974","journal-title":"Acta Vet Scand"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/BF03547462","article-title":"Acute rhabdomyolysis (tying\u2010up) in Standardbred horses. 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