{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:32:17Z","timestamp":1784698337199,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3879,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed single\u2010fiber electromyography (SFEMG) and correlated the results with muscle\u2010biopsy histochemistry in 56 patients with various neuromuscular diseases. Increased muscle\u2010fiber density, delineated by SFEMG, was most prominent in diseases of ordinary denervation, namely motor neuron disorders and peripheral neuropathies, and it correlated with histochemical fiber type grouping. Both phenomena reflect denervation followed by reinnervation. In patients with central core disease and rod disease, fiber density was not increased despite massive type I fiber predominance. The normal distribution of type I fiber subtypes in those patients indicated that their fiber predominance was not due to sprouting and reinnervation, but probably to paucity of the type II fibers. In type I fiber hypotrophy with central nuclei, fiber density was increased, perhaps attributable to the small diameter and consequent denser packing of the type I fibers. Fiber density was slightly increased in the majority of patients with acidmaltase deficiency, limb\u2010girdle dystrophy, and polymyositis, in nearly half with mitochondrial myopathy, and in 1 older Duchenne dystrophy patient. In these myopathic disorders, myogenous deinnervation (followed by reinnervation) is one possible explanation. Normal fiber density was present in all patients with muscle phosphorylase deficiency, myotonia congenita, and in the hypokalemic periodic paralysis patients under age 40. \u00a9 1994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880170314","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:32:51Z","timestamp":1104568371000},"page":"345-353","source":"Crossref","is-referenced-by-count":38,"title":["Single\u2010fiber electromyography in neuromuscular disorders: Correlation of muscle histochemistry, single\u2010fiber electromyography, and clinical findings"],"prefix":"10.1002","volume":"17","author":[{"given":"Tulio E.","family":"Bertorini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Stalberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo P.","family":"Yuson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. King","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.9.879"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.3.263"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(74)90106-3"},{"key":"e_1_2_1_5_2","first-page":"99","article-title":"The histologic diagnosis of neuromuscular diseases: a review of 79 biopsies","volume":"47","author":"Brooke MH","year":"1966","journal-title":"Arch Phys Med"},{"key":"e_1_2_1_6_2","series-title":"Ann NY Acad Sci","first-page":"121","author":"Brooke MH","year":"1974"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.11.1046"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.7.662"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/191389a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/84.2.167"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.12.11.778"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460190026003"},{"key":"e_1_2_1_13_2","first-page":"80","article-title":"Muscle biopsy","volume":"39","author":"Engel WK","year":"1965","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_1_14_2","first-page":"90","volume-title":"Neurological Diagnostic Techniques","author":"Engel WK","year":"1966"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)32067-3"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(68)90015-8"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1968.00470340121011"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480200003001"},{"key":"e_1_2_1_19_2","series-title":"Advances in Neuromuscular Diseases","first-page":"19","author":"Engel WK","year":"1971"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197308302890919"},{"key":"e_1_2_1_21_2","first-page":"141","volume-title":"New Developments in Electromyography and Clinical Neurophysiology","author":"Engel WK","year":"1973"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.2.173"},{"key":"e_1_2_1_23_2","first-page":"277","volume-title":"Pathogenesis of the Human Muscular Dystrophies","author":"Engel WK","year":"1977"},{"key":"e_1_2_1_24_2","first-page":"1555","volume-title":"Scientific Approaches to Clinical Neurology","author":"Emgel WK","year":"1977"},{"key":"e_1_2_1_25_2","first-page":"1572","volume-title":"Scientific Approaches to Clinical Neurology","author":"Engel WK","year":"1977"},{"key":"e_1_2_1_26_2","first-page":"1667","volume-title":"Scientific Approaches to Clinical Neurology","author":"Engel WK","year":"1977"},{"key":"e_1_2_1_27_2","first-page":"1250","volume-title":"Scientific Approaches to Clinical Neurology","author":"Engel WK","year":"1977"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880010103"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.12.1177"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90023-3"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.5.447"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/2151509a0"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/24.9.965713"},{"key":"e_1_2_1_34_2","first-page":"113","volume-title":"New Developments in Electromyography and clinical Neurophysiology","author":"Stalberg E","year":"1973"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(75)90166-5"},{"key":"e_1_2_1_36_2","volume-title":"Single Fiber Elertromyography","author":"Stalberg E","year":"1979"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880100704"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90163-9"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120710"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490180048011"},{"key":"e_1_2_1_41_2","first-page":"35","volume-title":"New Developments in Electromyography and Clinical Neurophysiology","author":"Warmolts JR","year":"1973"}],"container-title":["Muscle &amp; 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