{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:27:01Z","timestamp":1770773221764,"version":"3.50.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3787,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article describes a 37\u2010year\u2010old woman with progressive external ophthalmoplegia, peripheral neuropathy, and chronic intractable diarrhea. Laboratory studies disclosed lactic acidosis, ragged red fibers lacking cytochrome c oxidase, high\u2010normal muscular mitochondrial enzymes, demyelinating neuropathy, leukoencephalopathy and multiple mitochondrial DNA deletions. This is the fourth patient described with this clinical syndrome, which represents a separate entity among multisystemic mitocnondrial disorders. The patient described here is the first with this syndrome to have multiple mitochondrial DNA deletions. \u00a9 1994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880170616","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:27:27Z","timestamp":1104546447000},"page":"667-674","source":"Crossref","is-referenced-by-count":45,"title":["Ophthalmoplegia, demyelinating neuropathy, leukoencephalopathy, myopathy, and gastrointestinal dysfunction with multiple deletions of mitochondrial DNA: A mitochondrial multisystem disorder in search of a name"],"prefix":"10.1002","volume":"17","author":[{"given":"Antonino","family":"Uncini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Servidei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Manfredi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sabatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"di Muzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mirabella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"di Mauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Tonali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0016-5085(83)80133-4","article-title":"A familial visceral myopathy with external ophthalmoplegia and autosomal recessive transmission","volume":"84","author":"Anuras S","year":"1983","journal-title":"Gastroenterology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688189"},{"issue":"1","key":"e_1_2_1_4_2","first-page":"294","article-title":"MNGIE syndrome: report of 2 new patients [abstract]","volume":"40","author":"Blake D","year":"1990","journal-title":"Neurology"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1992.tb00679.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.4.544"},{"key":"e_1_2_1_7_2","first-page":"643","article-title":"Autosomal dominant deletions of the mitochondrial genome in a case of progressive encephalomyopathy","volume":"48","author":"Cormier V","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-01082-7.50020-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220409"},{"key":"e_1_2_1_10_2","first-page":"665","volume-title":"The Molecular and Genetic Bases of Neurological Diseases","author":"Di Mauro S","year":"1993"},{"key":"e_1_2_1_11_2","volume-title":"Muscle biopsy. 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