{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:09:58Z","timestamp":1791544198469,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3757,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Expression of the myoglobin (Mb) gene in skeletal muscle was studied in patients with Duchenne muscular dystrophy (DMD), polymyositis (PM), or amyotrophic lateral sclerosis (ALS) by measuring Mb concentration by radioimmunoassay and Mb messenger ribonucleic acid (RNA) (MbmRNA) levels by Northern blot analysis. Mb concentrations in the muscle cells (Mb\/noncollagenous protein) were decreased in patients with DMD, PM, or ALS. However, while Mb concentrations per MbmRNA content (Mb\/MbmRNA) were decreased in DMD and PM patients, these values were normal in ALS patients. These results suggest that Mb synthesis is increased in muscles of DMD and PM patients, but is not sufficient to compensate for the excessive loss of Mb from the affected muscles, and that the synthesis is decreased in the muscles of ALS patients. \u00a9 1994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880170703","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:15:14Z","timestamp":1104549314000},"page":"720-724","source":"Crossref","is-referenced-by-count":5,"title":["Expression of myoglobin gene in skeletal muscle of patients with neuromuscular diseases"],"prefix":"10.1002","volume":"17","author":[{"given":"Hisaomi","family":"Kawai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Naruo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(85)90033-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880070811"},{"key":"e_1_2_1_4_2","first-page":"84","volume-title":"Pathology of Skeletal Muscle","author":"Carpenter S","year":"1984"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130204"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0740237"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.5.C1092"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880010407"},{"key":"e_1_2_1_10_2","first-page":"474","article-title":"Myoglobin","volume":"28","author":"Kawai H","year":"1988","journal-title":"Neurol Med (Tokyo)"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00857525"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880100207"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880140409"},{"key":"e_1_2_1_14_2","first-page":"461","article-title":"Activation of the intramyofibral autophagic\u2010lysosomal system in muscular dystrophy","volume":"127","author":"Kominami E","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0021-9258(18)56484-X","article-title":"A reference base and system for analysis of muscle constitutent","volume":"182","author":"Lilienthal JL","year":"1950","journal-title":"J Biol Chem"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/241204a0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00369442"},{"key":"e_1_2_1_18_2","first-page":"341","article-title":"Radioimmunoassay for human myoglobin: methods and results in patients with skeletal muscle or myocardial disorders","volume":"92","author":"Miyoshi K","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880070508"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90185-X"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.239.4839.487"},{"key":"e_1_2_1_22_2","first-page":"7.39","volume-title":"Molecula cloning. 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