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The factors giving rise to these discharges are not well understood. Fasciculations may be related to chemical excitation of motor nerve terminals, whereas cramps may result from mechanical excitation of motor nerve terminals during muscle shortening. \u00a9 1994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880171102","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:29:35Z","timestamp":1104568175000},"page":"1243-1249","source":"Crossref","is-referenced-by-count":137,"title":["The origin of muscle fasciculations and cramps"],"prefix":"10.1002","volume":"17","author":[{"given":"Robert B.","family":"Layzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330207"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1944.tb10033.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050305"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1942.02830090020005"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1949.02310080003001"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(53)90090-4"},{"key":"e_1_2_1_8_2","first-page":"88","article-title":"Myokymia and the benign fasciculation of muscle cramps","volume":"61","author":"Denny\u2010Brown D","year":"1948","journal-title":"Trans Assoc Am Phys"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/61.3.311"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1944.02290270053006"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1946.02300200033002"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01761428"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198610000-00010"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.12.1375"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.1.118"},{"key":"e_1_2_1_16_2","first-page":"235","article-title":"Muscular cramp mechanism","volume":"33","author":"Lanari A","year":"1973","journal-title":"Medicina"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1915.sp001718"},{"key":"e_1_2_1_18_2","first-page":"135","volume-title":"Motor Neuron Diseases: Research on Amyotrophic Lateral Sclerosis and Related Disorders","author":"Lambert EH","year":"1969"},{"key":"e_1_2_1_19_2","first-page":"3462","volume-title":"Myology","author":"Layzer RB","year":"1994"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1940.3.3.269"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.45.6.539"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1965.00470050043005"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(57)90118-9"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880161113"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/66.1.1"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196909042811004"},{"key":"e_1_2_1_27_2","first-page":"413","article-title":"Fasciculations \u010forigine p\u00e9riph\u00e9rique","volume":"11","author":"Roth G","year":"1971","journal-title":"Electromyogr din Neurophysiol"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410120607"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(84)90152-7"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(87)90006-X"},{"key":"e_1_2_1_31_2","first-page":"120","article-title":"Physiological and chemical studies of neuromuscular disorders","volume":"64","author":"Russel CK","year":"1938","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.5.458"},{"key":"e_1_2_1_33_2","first-page":"646","article-title":"Origin offibrillary twitchings","volume":"15","author":"Shelden CH","year":"1940","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1988.tb05883.x"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1988.tb05884.x"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222202"},{"key":"e_1_2_1_37_2","series-title":"Ann NY Acad Sci","first-page":"517","author":"Standaert FG","year":"1967"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1943.02290130030003"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1947.tb08126.x"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050312"}],"container-title":["Muscle &amp; 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