{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:03:55Z","timestamp":1698296635431},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3634,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a 27 year\u2010old man treated for bilateral optic neuritis 5 and 3 years before who within a few months developed sensori\u2010 motor disorders of the arms and legs Characterized by asymmetric distribution and distal prominence. In addition to sensorimotor defects, which were particularly marked in the left arm and right leg, clinical examination showed nearly generalized areflexia. Electrophysiological studies revealed a rnultifocal neuropathy with persistent distal and proximal conduction blocks associated with a considerable slowing of motor nerve conduction, as well as central nervous system involvement indicated by motor\u2010, somatosensory\u2010, and visual\u2010evoked potentials. CSF analysis showed a mildly elevated protein level; anti\u2010GM, activity was negative. Sural nerve biopsy revealed onion\u2013bulb\u2010like formations, and cerebral MRI showed a small, isolated, and aspecific high signal for white matter. First described by Lewis and Sumner in 1982, rnultifocal neuropathy with persistent conduction blocks may be associated with central demyelination. Our case is compared with 3 similar ones in the literature, and the favorable effects of steroid therapy are emphasized. \u00a9 1994 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880171106","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:29:35Z","timestamp":1104568175000},"page":"1278-1285","source":"Crossref","is-referenced-by-count":8,"title":["Central nervous system involvement in multifocal demyelinating neuropathy with persistent conduction block"],"prefix":"10.1002","volume":"17","author":[{"given":"Yann","family":"P\u00e9r\u00e9on","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jardel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Guillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Guih\u00e9neuc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"30","article-title":"Multifocal pseudohypertrophic neuropathy","volume":"90","author":"Adams RD","year":"1965","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_1_3_2","first-page":"575","article-title":"Chronic relapsing demyelinating neuropathy of multiple mononeuropathy type","volume":"23","author":"Baba M","year":"1985","journal-title":"Clin Neurol (Tokyo)"},{"key":"e_1_2_1_4_2","first-page":"169","article-title":"The pathology of multifocal conduction block","volume":"34","author":"Bennet RD","year":"1984","journal-title":"Neurology"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/archneur.1988.00520280101025","article-title":"Proximal chronic inflammatory polyneuropathy with multifocal conduction block","volume":"45","author":"Bradley WG","year":"1988","journal-title":"Arch Neurol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93267-Q"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.9.864"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.506"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93339-O"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510020057008"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.9.958"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.8.1291"},{"key":"e_1_2_1_13_2","first-page":"4","volume-title":"Aquisitions r\u00e9centes en \u00e9lectromyographie","author":"M\u00e9tral S","year":"1992"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141005"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.1.106"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1987.00520200087025"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880110203"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141002"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280206"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000116045"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.8.1287"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150113"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.1.53"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314295"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314355"},{"key":"e_1_2_1_26_2","first-page":"26","article-title":"Motor neuropathy with multifocal conduction blocks","volume":"11","author":"Van den Bergh P","year":"1988","journal-title":"Muscle Nerve"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160102"},{"key":"e_1_2_1_28_2","first-page":"220","article-title":"Treatment of multifocal motor neuropathy with a high dosage of intravenous immunoglobulin","volume":"16","author":"Yuki M","year":"1993","journal-title":"Muscle Nerve"}],"container-title":["Muscle &amp; 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