{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:18:17Z","timestamp":1760782697005,"version":"3.32.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3573,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heat\u2010shock\/stress proteins (HSPs) are induced in response to stressful conditions and are essential for survival during and after cellular stress. We investigated whether dystrophin deficiency in muscle from Duchenne muscular dystrophy (DMD) patients induces HSPs. Immunohistochemical studies were performed on cryosections from normal muscle, heat\u2010shocked muscle, and muscle from patients with DMD, dermatomyositis, and mitochondrial myopathy using antibodies against HSP 72\/73, HSP 72, HSP 90, groEL (HSP 65 homologue), and ubiquitin. Computer\u2010assisted image processing revealed a significant (<jats:italic>P<\/jats:italic>&lt;0.05) induction of HSP 72\/73, 72, 65, and ubiquitin in hypercontracted fibers; HSP 90 and ubiquitin in regenerating fibers; and ubiquitin in macrophage invaded necrotic fibers of DMD muscle. No significant induction of HSPs was observed in dermatomyositis or mitochondrial myopathies. The stress response induced in DMD may relate to the metabolic stress characteristic of the disease and could represent and autoprotective mechanism. Manipulation of this protective response may reduce injury and have potential therapeutic application.\u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880180105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:30:29Z","timestamp":1104546629000},"page":"23-31","source":"Crossref","is-referenced-by-count":30,"title":["Expression of heat\u2010shock\/stress proteins in duchenne muscular dystrophy"],"prefix":"10.1002","volume":"18","author":[{"given":"Liza","family":"Bornman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George S.","family":"Gericke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara S.","family":"Polla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barend P.","family":"Lotz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(92)90023-Y"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(89)90193-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3175623"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/187248a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90460-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.5.439"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/01902148909069611"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480280083010"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.3.1081"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90573-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.001541"},{"key":"e_1_2_1_13_2","first-page":"1185","volume-title":"Myology","author":"Engel AG","year":"1986"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1990.tb01055.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.07.110191.000325"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)81039-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2049-2_8"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.3.345"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bb.21.060192.001453"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90611-2"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90579-4"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103283241303"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000319104"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/ajcp\/75.6.816","article-title":"The use of anti\u2010avidin and avidin\u2010biotin\u2010peroxidase complex in immunoperoxidase techniques","volume":"75","author":"Hsu SM","year":"1981","journal-title":"Am J Pathol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230485"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"C77","DOI":"10.1152\/ajpcell.1990.259.1.C77","article-title":"Calcium and the heat shock response in the human monocytic line U\u2010937","volume":"259","author":"Kantengwa S","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90504-6"},{"key":"e_1_2_1_28_2","first-page":"2240","article-title":"Induction of thermotolerance and heat shock protein synthesis in normal and respiration deficient chick embryo fibroblasts","volume":"45","author":"Landry J","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-066290-6.50017-6"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.55.070186.005443"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.261.5.C774"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.9.1466"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90349-5"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"14201","DOI":"10.1016\/S0021-9258(18)67004-8","article-title":"Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. 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