{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:03:37Z","timestamp":1792098217233,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3514,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been suggested that the primary site of damage in motor neuron disease (MND) is the cortical motor neuron, with secondary degeneration of spinal motor neurons. To test this hypothesis, we sought to determine if loss of corticomotoneurons in MND precedes spinal motor neuron loss. The density of corticomotoneurons was measured in 18 MND and 9 control cases using 10\u2010\u03bcm horizontal sections of motor cortex in the hand\/arm region. The density of spinal motor neurons was measured in 10\u2010\u03bcm transverse sections of the lower cervical spinal cord. Corticomotoneuron and spinal motor neuron densities were decreased in MND cases compared to controls, but in MND cases there was poor correlation (<jats:italic>r<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup> = 0.06) between corticomotoneuron and spinal motor neuron densities. The results indicate that corticomotoneuron and spinal motor neurons are lost at different rates in different MND patients, and that corticomotoneuron loss is unlikely to be a primary event in MND.\u00a9 1995 John Wiley &amp;Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880180308","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:34:58Z","timestamp":1104546898000},"page":"314-318","source":"Crossref","is-referenced-by-count":52,"title":["Motor neuron disease: A primary disorder of corticomotoneurons?"],"prefix":"10.1002","volume":"18","author":[{"given":"Roger","family":"Pamphlett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Kril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Ming","family":"Hng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90030-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(76)90175-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1941.02280240094006"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150215"},{"key":"e_1_2_1_6_2","first-page":"S588","article-title":"Imaging of immunohistochemically identified neurons using IBM compatible and Macintosh computers","volume":"34","author":"Halasz P","year":"1989","journal-title":"Neurosci Lett"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150216"},{"key":"e_1_2_1_8_2","first-page":"S83","article-title":"Cortical function in progressive muscular atrophy and amyotrophic lateral sclerosis","volume":"4","author":"Kew JM","year":"1993","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.2.843"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1940.02280100020002"},{"key":"e_1_2_1_11_2","volume-title":"The Pyramidal Tract. Its Status in Medicine","author":"Lassek AM","year":"1954"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1953.02320260029002"},{"key":"e_1_2_1_13_2","first-page":"15","volume-title":"Human Motor Neuron Diseases","author":"Mulder DW","year":"1982"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901950212"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454899"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1987.0039"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199305000-00077"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150217"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.7.2.124"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.880180308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.880180308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:31:21Z","timestamp":1698287481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.880180308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1002\/mus.880180308"],"URL":"https:\/\/doi.org\/10.1002\/mus.880180308","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}