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To determine whether muscle VGCC properties are altered in ALS, VGCC\u2010enriched subsarcolemmal membrane fractions were prepared from biopsied quadriceps muscle of patients with ALS, with other neurologic diseases, or without apparent muscle disease, and tested for DHP binding with [<jats:sup>3<\/jats:sup>H]PN200\u2010110. ALS muscle VGCCs from muscle fractions of most other patients, independent of denervation\u2010induced increases in DHP binding site number. Similarly elevated DHP binding affinities were observed in specimens from patients with autoimmune motor neuropathies, suggesting that ALS and immunemediated motoneuron disease share skeletal muscle L\u2010type VGCC alterations. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880180609","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:37:13Z","timestamp":1104547033000},"page":"620-627","source":"Crossref","is-referenced-by-count":9,"title":["Altered muscle calcium channel binding kinetics in autoimmune motoneuron disease"],"prefix":"10.1002","volume":"18","author":[{"given":"R. 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