{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:24:53Z","timestamp":1791271493873,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3392,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple symmetric lipomatosis (MSL) is characterized by a typical neck and shoulder distribution of subcutaneous lipomata and is often associated with polyneuropathy. Occasionally, the central nervous system (CNS) can be involved. Twelve of 14 patients in this retrospective study had clinical or electrophysiological evidence of a predominantly axonal polyneuropathy. Among those were 10 with alcohol abuse, but 2 patients without alcohol abuse also showed clinical or electrophysiological polyneuropathy. Clinical CNS involvement was present in 4 patients. CNS dysfunction was documented by evoked potentials in 8 subjects [prolonged latency or low amplitude of the motor response following cortical magnetic stimulation (4 patients), abnormal visually evoked potentials (4 patients) or somatosensory evoked potentials (SEP) (4 patients)]. These findings were compared to 10 chronic alcoholics without clinical signs of MSL. Five of these showed mild sensory neuropathy. Additionally, 2 also had delayed SEP latencies. Motor evoked potentials were normal in all controls. We propose that the multisystem involvement in MSL demonstrated here cannot be attributed to alcohol abuse alone. Biochemical studies have suggested mitochondrial dysfunction as the basis of the widespread neurological pathology in MSL. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880180704","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:37:31Z","timestamp":1104547051000},"page":"693-698","source":"Crossref","is-referenced-by-count":24,"title":["Neurological multisystem manifestation in multiple symmetric lipomatosis: A clinical and electrophysiological study"],"prefix":"10.1002","volume":"18","author":[{"given":"Markus","family":"Naumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertold","family":"Schalke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klopstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Reichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus W.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Wiesbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Viktor","family":"Toyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlheinz","family":"Reiners","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"279","volume-title":"Evozierte Potentiale","author":"Altenm\u00fcller E","year":"1989"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/276407a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290519"},{"key":"e_1_2_1_5_2","first-page":"168","article-title":"Lipomatosis symmetrica benigna und neurologische Komplikationen bei chronischem Alkoholismus","volume":"53","author":"Berlit P","year":"1982","journal-title":"Nervenarzt"},{"key":"e_1_2_1_6_2","first-page":"275","volume-title":"Lectures Illustrative of Various Subjects in Pathology and Surgery","author":"Brodie BC","year":"1846"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.8.1246"},{"key":"e_1_2_1_8_2","first-page":"371","volume-title":"Evoked Potentials in Clinical Medicine","author":"Chiappa KH","year":"1990"},{"key":"e_1_2_1_9_2","first-page":"111","volume-title":"Evoked Potentials in Clinical Medicine","author":"Chiappa KH","year":"1990"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198401000-00004"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198511000-00003"},{"key":"e_1_2_1_12_2","first-page":"104","volume-title":"Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice","author":"Kimura J","year":"1989"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.5.862"},{"key":"e_1_2_1_14_2","first-page":"29","article-title":"Normwerte und altersabh\u00e4ngige Ver\u00e4nderungen magneto\u2010elektrischer evozierter Muskel\u2010Summenaktionspotentiale","volume":"23","author":"Kloten H","year":"1992","journal-title":"Z EEG EMG"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(51)90405-9"},{"key":"e_1_2_1_16_2","first-page":"298","article-title":"De l'ad\u00e9nolipomatose symm\u00e9trique","volume":"1","author":"Launois P","year":"1898","journal-title":"Bull Mem Soc Med H\u01d2p Paris"},{"key":"e_1_2_1_17_2","first-page":"106","article-title":"\u00dcber den Fetthals (diffuses Lipom des Halses)","volume":"37","author":"Madelung OW","year":"1888","journal-title":"Langenbecks Arch Klin Chir"},{"key":"e_1_2_1_18_2","first-page":"193","article-title":"Etude de la conduction aff\u00e9rente dans le nerf saph\u00e9ne externe par la technique des potentiels \u00e9voqu\u00e9 c\u00e9r\u00e9braux","volume":"131","author":"N\u00f6el P","year":"1975","journal-title":"Rev Neurol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.5.1157"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70253-9"},{"key":"e_1_2_1_21_2","volume-title":"Subkortikale und kortikale sensibel evozierte Potentiale: Grenzen des Normalen, diagnostischer Wert bei ausgew\u00e4hlten Erkrankungen des peripheren und zentralen Nervensystems","author":"Vogel P","year":"1985"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(70)90025-0"}],"container-title":["Muscle &amp; 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