{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:40:15Z","timestamp":1758123615090},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3330,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Activities of nine lysosomal enzymes and pH\u2010dependent isozyme patterns of \u03b1\u2010mannosidase were examined in the skeletal muscle of patients with neuromuscular diseases, and the ratios of these enzyme activities in leukocytes to those in myocytes (L\/M ratio) were determined. The activities of enzymes with a high L\/M ratio were markedly increased in the muscles of patients with Duchenne muscular dystrophy (DMD), myotonic dystrophy (MyD), or polymyositis (PM). In contrast, those which showed a low L\/M ratio were increased in the muscles of amyotrophic lateral sclerosis (ALS) and disuse muscle atrophy (DUA). The isozyme pattern of \u03b1\u2010mannosidase in DMD muscle resembled that in leukocytes, while those in ALS and DUA muscle resembled that in normal muscle. These results may suggest that the increased activity of lysosomal enzymes in the muscles of patients with DMD, MyD, or PM is due primarily to infiltrating leukocytes, while that in patients with ALS or DUA is due to intramyofiber lysosomes. \u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880180913","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:38:47Z","timestamp":1104547127000},"page":"1009-1015","source":"Crossref","is-referenced-by-count":4,"title":["Lysosomal enzyme activities in skeletal muscle of patients with neuromuscular diseases"],"prefix":"10.1002","volume":"18","author":[{"given":"Hisaomi","family":"Kawai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Naruo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kunishige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.8.901"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880060304"},{"key":"e_1_2_1_4_2","first-page":"75","article-title":"Skeletal muscle lysosomes","volume":"43","author":"Bird JWC","year":"1975","journal-title":"Front Biol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90154-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/clinchem\/18.9.971","article-title":"Glucosidase in normal human leukocytes and abnormalities in GMI\u2010gangliosidosis","volume":"18","author":"Hindman J","year":"1972","journal-title":"Clin Chem"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.155.3758.86"},{"key":"e_1_2_1_9_2","first-page":"28","article-title":"Two sisters of mannosidosis: clinical manifestations and pathologic findings of the skeletal muscle","volume":"75","author":"Kawai H","year":"1986","journal-title":"J Jpn Soc Int Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690195"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01891236"},{"key":"e_1_2_1_12_2","first-page":"461","article-title":"Activation of the intramyofibral autophagic lysosomal system in muscular dystrophy","volume":"127","author":"Kominami E","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.54.070185.003215"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/322073a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(74)90841-9"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(71)80059-0"},{"key":"e_1_2_1_17_2","first-page":"341","article-title":"Radioimmunoassay for human myoglobin: methods and results in patients with skeletal muscle or myocardial disorders","volume":"92","author":"Miyoshi K","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1979.tb56562.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(73)90158-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000459032","article-title":"Altered \u03b1\u2010mannosidase isozymes in the liver in hepatic cirrhosis","volume":"27","author":"Robinson DB","year":"1982","journal-title":"Enzyme"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(72)80002-9"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(74)90352-3"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.64.37"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0120522"}],"container-title":["Muscle &amp; 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