{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:05:30Z","timestamp":1792674330382,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3300,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mdx mouse, a genetic homologue of human Duchenne muscular dystrophy (DMD), has been attributed with a greater regenerative capacity of its skeletal muscles. Here, we have tested the hypothesis that muscles of mdx mice regenerate better than those of nondystrophic animals. We studied muscle regeneration resulting from a denervation\u2010devascularization injury (DD) of extensor digitorum longus muscle (EDL) at 3 weeks and 2 months in mdx and wild\u2010type (C57BL\/10) mice. Histological and morphometrical studies of muscle regeneration were made from 3 to 180 days later. When DD was performed in 3\u2010week\u2010old C57BL\/10 mice, the percentages of nonperipheral nuclei in regenerated fibers decreased progressively over 3 months. This decrease did not occur in animals where DDs were performed at 2months, suggesting that two different populations of muscle precursor cells are mobilized in muscle regenration in mice at these two ages. Moreover, mdx EDL muscle regenerated similarly to the controls for up to 60 postoperative days, as shown by distribution of mean diameters and percentage of nonperipheral nuclei of muscle fibers. After 60 postoperative days, necrosis\/regeneration characteristics of mdx muscles recurred, suggesting that mdx\u2010regenerated muscle fibers remain susceptible to degeneration.\u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880181011","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:31:48Z","timestamp":1104546708000},"page":"1147-1154","source":"Crossref","is-referenced-by-count":79,"title":["Age\u2010related differences in regeneration of dystrophic (mdx) and normal muscle in the mouse"],"prefix":"10.1002","volume":"18","author":[{"given":"Christian","family":"Pastoret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Sebille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120705"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880140311"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01738755"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.4.1189"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001370202"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(76)90214-4"},{"key":"e_1_2_1_8_2","first-page":"189","article-title":"Muscle regeneration and aging","volume":"23","author":"Carlson BM","year":"1992","journal-title":"Monogr Devel Biol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(87)90219-X"},{"key":"e_1_2_1_10_2","first-page":"909","article-title":"Feline muscular dystrophy with dystrophin deficiency","volume":"135","author":"Carpenter JL","year":"1989","journal-title":"Am J Pathol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(08)60625-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1988.tb00890.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1988.tb00866.x"},{"key":"e_1_2_1_14_2","volume-title":"Muscle Biopsy: A Practical Approach","author":"Dubowitz V","year":"1985"},{"key":"e_1_2_1_15_2","volume-title":"Duchenne Muscular Dystrophy","author":"Emery AEH","year":"1987"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-1528-5_9"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(79)90035-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90579-4"},{"key":"e_1_2_1_19_2","first-page":"1991","volume-title":"Ordering the membrane\u2010cytoskeleton. 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