{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:18:39Z","timestamp":1776467919201,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3300,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Porcine malignant hyperthermia (MH) is an autosomal recessive disorder resulting from a mutation in the skeletal muscle sarcoplasmic reticulum (SR) Ca<jats:sup>2+<\/jats:sup> release channel. The Ca<jats:sup>2+<\/jats:sup> release properties of SR vesicles isolated from pigs heterozygous for the MH gene have been demonstrated previously to be intermediate to those of vesicles isolated from MH\u2010susceptible (MHS) and normal pigs. The Ca<jats:sup>2+<\/jats:sup> release channel is tetrameric, so the intermediate Ca<jats:sup>2+<\/jats:sup> release properties of heterozygous pig SR preparations could result either from populations of MHS and normal homotetramers, or populations of heterotetrameric Ca<jats:sup>2+<\/jats:sup> release channels with properties unique from those of the two types of homozygous channels. To discriminate between these possibilities, the single channel percent open time (P<jats:sub>o<\/jats:sub>) and channel dwell time distributions of SR Ca<jats:sup>2+<\/jats:sup> release channels were analyzed. These data suggest that the heterozygous porcine Ca<jats:sup>2+<\/jats:sup> release channel population must contain heterotetramers with properties distinct from those of either MHS or normal channels. The data also imply that the Ca<jats:sup>2+<\/jats:sup> release channel population in MHS humans who are heterozygous for a dominant mutation in this protein also contains heterotetrameric channels.\u00a9 1995 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880181013","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:31:48Z","timestamp":1104546708000},"page":"1167-1176","source":"Crossref","is-referenced-by-count":11,"title":["Ca<sup>2+<\/sup> Release channels of pigs heterozygous for malignant hyperthermia"],"prefix":"10.1002","volume":"18","author":[{"given":"Nirah H.","family":"Shomer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Mickelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles 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The Art of Scientific Computing","author":"Press WH","year":"1993"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"C125","DOI":"10.1152\/ajpcell.1993.264.1.C125","article-title":"Reconstitution of abnormalities in the malignant hyperthermia susceptible pig ryanodine receptor","volume":"264","author":"Shomer NH","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"C1253","DOI":"10.1152\/ajpcell.1994.267.5.C1253","article-title":"Caffeine stimulation of the malignant hyperthermia\u2010susceptible sarcoplasmic reticulum Ca2+ release channel","volume":"36","author":"Shomer NH","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80524-7"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.92.1.1"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.1991.261.2.C237","article-title":"Altered binding 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