{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:54:14Z","timestamp":1761216854678},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":3269,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lmmunohistochemical analyses were made of the superoxide dismutases (Mn\u2010SOD and CuiZn\u2010SOD) in biopsied muscles from 7 patients with mitochondrial encephalomyopathies that included mitochondrial encephalomyopathy, lactic acidosis and strokelike episodes (MELAS), and chronic progressive external ophthalmoplegia (CPEO). Mn\u2010SOD mainly was present in the subsarcolemmal region, but it also was found in a coarsely granular, reticular, or diffuse pattern of staining within the muscle fibers. These Mn\u2010SOD\u2010positive fibers corresponded almost completely to the ragged\u2010red fibers. The immunoreaction for CuiZn\u2010SOD was weakly positive in some of the muscle fibers positive for Mn\u2010SOD. In CPEO, Mn\u2010SOD\u2010positive fibers predominantly showed decreased cytochrome c oxidase (COX) activity. In MELAS, Mn\u2010SOD\u2010positive fibers tended to be stained deeply for COX although a few were COX\u2010negative. These findings suggest that Mn\u2010SOD\u2010positive fibers can be used to make a differential diagnosis between CPEO and MELAS and that in mitochondrial encephalomyopathies Mn\u2010SOD in the raggedred fibers may protect against oxidative stress. \u00a9 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/mus.880181108","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T02:32:33Z","timestamp":1104546753000},"page":"1265-1271","source":"Crossref","is-referenced-by-count":32,"title":["Superoxide dismutases of muscle in mitochondrial encephalomyopathies"],"prefix":"10.1002","volume":"18","author":[{"given":"Norio","family":"Ohkoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hldehlro","family":"Mizusawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuko","family":"Shiraiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin'Ichi","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1139\/o92-061"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1340707"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170602"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/348651a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/331717a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90125-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63504-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198905183202001"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00695049"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2020097"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(87)90071-5"},{"key":"e_1_2_1_14_2","first-page":"205","volume-title":"Progress in Neuropathology","author":"Nionaka I","year":"1991"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF00687425","article-title":"Muscle pathology in cytochrome c oxidase deficiency","volume":"77","author":"Nonaka I","year":"1988","journal-title":"Acta Neuropathol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(91)90118-Q"},{"key":"e_1_2_1_17_2","first-page":"363","article-title":"Intracellular localization of the copper\u2010zinc and manganese superoxide dismutases in rat liver parenchymal cells","volume":"55","author":"Slot JW","year":"1986","journal-title":"Lab Invest"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(85)90293-0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1910421"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1016\/S0021-9258(19)43735-6","article-title":"Superoxide dismutase: organelle specificity","volume":"248","author":"Weisiger RA","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1016\/S0021-9258(19)43735-6","article-title":"Mitochondria1 superoxide dismutase: site of synthesis and intramitochondrial localization","volume":"248","author":"Weisiger RA","year":"1973","journal-title":"J Biol Chem"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/339309a0"}],"container-title":["Muscle &amp; 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