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Currently, one of the main limitations of rapid tests is the high percentage of false negatives in the presence of variants and, in particular for the Omicron one. We demonstrate in this work the detection of SARS\u2010CoV\u20102 and the Omicron variant with a cost\u2010effective silicon nanosensor enabling high sensitivity, selectivity, and fast response. We have shown that a silicon (Si) nanowires (NW) platform detects both Sars\u2010CoV\u20102 and its Omicron variant with a limit of detection (LoD) of four effective copies (cps), without any amplification of the genome, and with high selectivity. This ultrasensitive detection of 4\u00a0cps allows to obtain an extremely early diagnosis paving the way for efficient and widespread tracking. The sensor is made with industrially compatible techniques, which in perspective may allow easy and cost\u2010effective industrialization.<\/jats:p>","DOI":"10.1002\/nano.202200188","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T09:35:20Z","timestamp":1672306520000},"page":"160-169","source":"Crossref","is-referenced-by-count":15,"title":["SARS\u2010CoV\u20102 and omicron variant detection with a high selectivity, sensitivity, and low\u2010cost silicon bio\u2010nanosensor"],"prefix":"10.1002","volume":"4","author":[{"given":"Antonio Alessio","family":"Leonardi","sequence":"first","affiliation":[{"name":"Dipartimento di Fisica e Astronomia \u201cEttore Majorana\u201d Universit\u00e0 degli studi di Catania  Catania Italy"},{"name":"CNR\u2010IMM Catania Universit\u00e0 Istituto per la Microelettronica e Microsistemi  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele Luigi","family":"Sciuto","sequence":"additional","affiliation":[{"name":"Lab SENS Beyond Nano CNR  Messina Italy"},{"name":"Dipartimento di Scienze Chimiche Biologiche, Farmaceutiche, ed Ambientali Universit\u00e0 degli studi di Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Lo Faro","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisica e Astronomia \u201cEttore Majorana\u201d Universit\u00e0 degli studi di Catania  Catania Italy"},{"name":"CNR\u2010IMM Catania Universit\u00e0 Istituto per la Microelettronica e Microsistemi  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Fazio","sequence":"additional","affiliation":[{"name":"Lab SENS Beyond Nano CNR  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche Biologiche, Farmaceutiche, ed Ambientali Universit\u00e0 degli studi di Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche Biologiche, Farmaceutiche, ed Ambientali Universit\u00e0 degli studi di Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Francioso","sequence":"additional","affiliation":[{"name":"CNR\u2010IMM Istituto per la Microelettronica e Microsistemi Via Monteroni University Campus  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Picca","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 degli studi di Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Nastasi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche Biologiche, Farmaceutiche, ed Ambientali Universit\u00e0 degli studi di Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia Umana dell'adulto e dell'et\u00e0 evolutiva Gaetano Barresi Universit\u00e0 degli studi Messina  Gazzi (Me) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Spinella","sequence":"additional","affiliation":[{"name":"Lab SENS Beyond Nano CNR  Messina Italy"},{"name":"CNR\u2010IMM Istituto per la Microelettronica e Microsistemi Zona Industriale  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Knoll","sequence":"additional","affiliation":[{"name":"Department of Scientific Coordination and Management Danube Private University  Krems Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Irrera","sequence":"additional","affiliation":[{"name":"Lab SENS Beyond Nano CNR  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Conoci","sequence":"additional","affiliation":[{"name":"Lab SENS Beyond Nano CNR  Messina Italy"},{"name":"Dipartimento di Scienze Chimiche Biologiche, Farmaceutiche, ed Ambientali Universit\u00e0 degli studi di Messina  Messina Italy"},{"name":"CNR\u2010IMM Istituto per la Microelettronica e Microsistemi Zona Industriale  Catania Italy"},{"name":"Dipartimento di Chimica \"G. 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