{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:16:55Z","timestamp":1787991415471,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nanophotonics"],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Accurate detection of nanoparticles in liquids is essential across drug delivery, diagnostics, and environmental monitoring. Dynamic light scattering (DLS), the current gold\u2010standard technique, relies on single\u2010scattering events and requires prior knowledge of sample temperature and optical properties, limiting its sensitivity at low particle concentrations and increasing system cost and complexity. Here, we present a lensless, cost\u2010effective speckle\u2010based method that exploits multiple light scattering to overcome these limitations. A custom\u2010machined aluminum sample holder uniformly illuminates the entire sample volume with a randomized coherent light field via repeated diffuse reflections. Subtle nanoparticle motions modulate the phase of the scattered light, producing time\u2010varying speckle patterns captured by a CMOS camera without any imaging optics. Temporal correlation analysis of the speckle time series quantifies nanoparticle dynamics without requiring prior sample information. The method detects nanoparticles at concentrations as low as 10\n                    <jats:sup>5<\/jats:sup>\n                    particles\/mL, which is at least 10\n                    <jats:sup>3<\/jats:sup>\n                    \u201310\n                    <jats:sup>4<\/jats:sup>\n                    \u2010fold below the DLS detection limit for sub\u2010200\u00a0nm particles. Under fixed\u2010concentration conditions, an empirical calibration model achieves semi\u2010quantitative size determination in the 100\u2013200\u00a0nm range with 95% prediction intervals within \u00b1\u00a07\u00a0nm. The proposed platform therefore offers a versatile, field\u2010deployable solution for ultrasensitive nanoparticle characterization in liquid media.\n                  <\/jats:p>","DOI":"10.1002\/nap2.70193","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:46:13Z","timestamp":1783277173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Lensless Compact Optical System for Ultrasensitive Nanomaterial Detection in Liquid Media via Exploiting Multiple Light Scattering"],"prefix":"10.1002","volume":"15","author":[{"given":"Jeonggyo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Energy Systems Research Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Ajou Energy Science Research Center Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-3514","authenticated-orcid":false,"given":"Jun\u2010Won","family":"Kook","sequence":"additional","affiliation":[{"name":"Ajou Energy Science Research Center Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae\u2010Nam","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Energy Systems Research Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungman","family":"Cho","sequence":"additional","affiliation":[{"name":"The Wave Talk. Inc.  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u2010Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-8272","authenticated-orcid":false,"given":"Jongkook","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Energy Systems Research Ajou University  Suwon South Korea"},{"name":"Department of Chemical Engineering Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0065-7486","authenticated-orcid":false,"given":"Sungju","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Energy Systems Research Ajou University  Suwon South Korea"},{"name":"Department of Chemistry Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-2229","authenticated-orcid":false,"given":"Chung\u2010Yul","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Energy Systems Research Ajou University  Suwon South Korea"},{"name":"Department of Chemistry Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-2792","authenticated-orcid":false,"given":"Jonghee","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Energy Systems Research Ajou University  Suwon South Korea"},{"name":"Department of Physics Ajou University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoso.2024.101103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219657"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010023\u201000246\u20107"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9010065"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010020\u20100383\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.62347\/XJKL4863"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202302673"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.4c05649"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202100186"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b06903"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3973841"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876\u2010022\u201002293\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2021.109704"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4EN00143E"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2017.05.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SM01597K"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551\u2010016\u20100218\u20106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106501\/ac3ea5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c06750"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lpor.202300494"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1103\/physrevlett.93.037401"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c07734"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4935503"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300126"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108417"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036\u2010025\u201000490\u2010x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5007018"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2022.100292"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957\u20100233\/12\/5\/201"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.111729"}],"container-title":["Nanophotonics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nap2.70193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nap2.70193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nap2.70193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:46:22Z","timestamp":1787989582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nap2.70193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,5]]},"references-count":31,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7,13]]}},"alternative-id":["10.1002\/nap2.70193"],"URL":"https:\/\/doi.org\/10.1002\/nap2.70193","archive":["Portico"],"relation":{},"ISSN":["2192-8614","2192-8614"],"issn-type":[{"value":"2192-8614","type":"print"},{"value":"2192-8614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,5]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70193"}}