{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:04:48Z","timestamp":1761127488429},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,3,27]],"date-time":"2002-03-27T00:00:00Z","timestamp":1017187200000},"content-version":"vor","delay-in-days":85,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate the effects of a \u03b23\u2010adrenoceptor (AR) agonist (CL\u2010316243), an \u03b11\u2010AR agonist (phenylephrine), and a loop diuretic (furosemide) on the spontaneous rhythmic contractions of the isolated canine ureter and on an acute ureteral obstruction produced by inflation of a balloon catheter in anesthetized dogs. In the isolated ureter, CL\u2010316243 concentration dependently reduced both the amplitude and frequency of the rhythmic contractions (pD<jats:sub>2<\/jats:sub>: 7.19\u2009\u00b1\u20090.33), whereas phenylephrine significantly enhanced both variables (pD<jats:sub>2<\/jats:sub>: 5.26\u2009\u00b1\u20090.09) and furosemide reduced them only slightly. In the acute ureteral obstruction model, the intraureteral pressure (IUP) gradually rose to reach a plateau of 58.9 mm Hg after inflation of a balloon catheter within the lower ureter. Intravenous administration of CL\u2010316243 (0.3 \u03bcg\/kg) significantly reduced the elevated IUP and the resumed urine flow (UF), leading to a sustained reduction in the IUP. In contrast, the IUP continued to increase above the plateau level for 10 minutes after phenylephrine administration (10 \u03bcg\/kg) and for 30 minutes after furosemide administration (1,000 \u03bcg\/kg). In the phenylephrine group, the UF resumed when the IUP reached 75.8 mm Hg, and thereafter the IUP gradually decreased in parallel with the increase in the UF. From these results, we conclude that in dogs, CL\u2010316243 reduces the IUP by allowing the UF to resume as a result of a relaxation of ureter at the obstruction site, whereas with phenylephrine, the reduction in the IUP is secondary to a resumption in the UF resulting from an induced contraction of ureter that causes an increase in hydrostatic pressure above the obstruction site. Neurourol. Urodynam. 21:251\u2013257, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/nau.10008","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:25:36Z","timestamp":1030317936000},"page":"251-257","source":"Crossref","is-referenced-by-count":14,"title":["Modification of ureteral motility and promotion of urine flow around an intraureteral obstruction by CL\u2010316243, phenylephrine, and furosemide in dogs"],"prefix":"10.1002","volume":"21","author":[{"given":"Yoshitaka","family":"Tomiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masuo","family":"Akahane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Chol","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)32511-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40037-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb13387.x"},{"issue":"1","key":"e_1_2_1_5_1","first-page":"1","article-title":"Ureteral stones","volume":"1","author":"Holmlund D","year":"1968","journal-title":"Scand J Urol Nephrol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1987.tb04833.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430320203"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1970.tb10018.x"},{"key":"e_1_2_1_9_1","first-page":"1","article-title":"Percutaneous puncture of renal pelvis, intrapelvic pressure and the concentrating capacity of the kidney in hydronephrosis","volume":"599","author":"Michaelson G","year":"1974","journal-title":"Acta Med Scand"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6777(1994)13:3<315::AID-NAU1930130313>3.0.CO;2-G"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.152.111"},{"key":"e_1_2_1_12_1","first-page":"67","article-title":"Effects of \u03b2\u2010adrenergic stimulation on the acutely obstructed ureter in dogs","volume":"292","author":"Murakami M","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67200-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282158"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1967.tb11780.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00255531"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00360-4"},{"key":"e_1_2_1_18_1","first-page":"839","volume-title":"Campbell's urology","author":"Weiss RM","year":"1997"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.10008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.10008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T01:34:51Z","timestamp":1700530491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.10008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1002\/nau.10008"],"URL":"https:\/\/doi.org\/10.1002\/nau.10008","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}