{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:49:13Z","timestamp":1770504553652,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,10,10]],"date-time":"2002-10-10T00:00:00Z","timestamp":1034208000000},"content-version":"vor","delay-in-days":282,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims.<\/jats:title><jats:p>To investigate the effects of selective \u03b2<jats:sub>2<\/jats:sub>\u2010 and selective \u03b2<jats:sub>3<\/jats:sub>\u2010adrenoceptor (AR) agonists on prostaglandin (PG) E<jats:sub>2<\/jats:sub>\u2010induced bladder hyperactivity in conscious free\u2010moving rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Female Sprague\u2010Dawley rats were anesthetized for implantation of bladder, intravenous, and intra\u2010arterial catheters. The effects of a \u03b2<jats:sub>3<\/jats:sub>\u2010AR agonist (CL316,243) on cystometric and cardiovascular parameters were assessed in conscious rats. Intravesical instillation of PGE<jats:sub>2<\/jats:sub> (20\u201360 \u03bcM, 6 mL\/hr) in conscious rats produced a concentration\u2010dependent increase in voiding frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>In this model i.v. CL316,243 (\u03b2<jats:sub>3<\/jats:sub>\u2010AR agonist) reduced basal bladder pressure, increased micturition volume, and prolonged micturition interval in a dose\u2010dependent manner, without affecting threshold pressure or micturition pressure. On the other hand, i.v. procaterol (\u03b2<jats:sub>2<\/jats:sub>\u2010AR agonist) did not counteract the bladder hyperactivity. Atropine (muscarinic antagonist) reduced micturition pressure and micturition volume, and shortened micturition interval. CL316,243 slightly decreased mean blood pressure and increased heart rate only when given at high doses (10 and 100 \u03bcg\/kg, i.v.). In contrast, procaterol caused a significant decrease in mean blood pressure and a significant increase in heart rate. Atropine significantly increased heart rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>The present results clearly demonstrated that the \u03b2<jats:sub>3<\/jats:sub>\u2010AR agonist prolonged the micturition interval without producing significant cardiovascular side effects. The human detrusor, like the rat detrusor, relaxes on \u03b2<jats:sub>3<\/jats:sub>\u2010AR stimulation. Provided that these results are valid in humans, selective \u03b2<jats:sub>3<\/jats:sub>\u2010AR agonists might be clinically useful for controlling a certain type of bladder overactivity. Neurourol. Urodynam. 21:558\u2013565, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.10034","type":"journal-article","created":{"date-parts":[[2002,10,16]],"date-time":"2002-10-16T15:26:36Z","timestamp":1034781996000},"page":"558-565","source":"Crossref","is-referenced-by-count":64,"title":["Effects of \u03b2<sub>3<\/sub>\u2010adrenoceptor stimulation on prostaglandin E<sub>2<\/sub>\u2013induced bladder hyperactivity and on the cardiovascular system in conscious 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