{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:47:53Z","timestamp":1774464473598,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,3,27]],"date-time":"2002-03-27T00:00:00Z","timestamp":1017187200000},"content-version":"vor","delay-in-days":85,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serotonin (5\u2010HT) receptors are widely distributed in the central nervous system, including several areas involved in the control of micturition reflex pathways. However, the roles of the different subtypes of 5\u2010HT receptors are not well known. We studied in normal, conscious rats, the effects on the cystometrogram of intracerebroventricular (i.c.v.) administration of 5\u2010HT, 8\u2010hydroxy\u20102\u2010(di\u2010N\u2010propylaminotetralin) (8\u2010OH\u2010DPAT; agonist at 5\u2010HT<jats:sub>1A<\/jats:sub> receptors), \u03b1\u2010methyl\u20105\u2010hydroxytryptamine maleate (agonist at 5\u2010HT<jats:sub>2<\/jats:sub> receptors), 2\u2010methyl\u20105\u2010hydroxytryptamine hydrochloride (agonist at 5\u2010HT<jats:sub>3<\/jats:sub> receptors), and 1\u2010(4\u2010amino\u20105\u2010chloro\u20102methoxyphenyl)\u20103\u2010(1\u2010<jats:italic>n<\/jats:italic>\u2010butyl\u20104piperidinyl)\u20101\u2010propanone hydrochloride (RS67506; agonist at 5\u2010HT<jats:sub>4<\/jats:sub> receptors). Female Sprague\u2010Dawley rats, weighing approximately 230 g, were used. A polyethylene catheter was inserted into the bladder through the dome for cystometric investigations. For administration of drugs, a catheter was implanted into the right cerebral ventricle. Three days after implantation of the bladder catheter, continuous cystometry was performed. Administration of 5\u2010HT (6 nmol\/kg i.c.v.), 8\u2010OH\u2010DPAT (6 nmol\/kg), \u03b1\u2010methyl\u20105\u2010hydroxytryptamine maleate (6 nmol\/kg), or RS67506 hydrochloride (6 nmol\/kg) significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) increased micturition pressure and decreased bladder capacity and micturition volume. The effects increased in a dose\u2010dependent manner (18, 60 nmol\/kg). Intracerebroventricular administration of 2\u2010methyl\u20105\u2010hydroxytryptamine hydrochloride (60 nmol\/kg) caused no change in the cystometric parameters. The results suggest that in normal conscious rats, at the supraspinal level, 5\u2010HT (via 5\u2010HT<jats:sub>1A<\/jats:sub>, 5\u2010HT<jats:sub>2<\/jats:sub>, and 5\u2010HT<jats:sub>4<\/jats:sub> receptors) can enhance the micturition reflex induced by bladder filling. Whether this means that 5\u2010HT<jats:sub>1A<\/jats:sub>, 5\u2010HT<jats:sub>2<\/jats:sub>, and 5\u2010HT<jats:sub>4<\/jats:sub> receptors can be targets for drugs meant for treatment of bladder hyperactivity, should be explored. Neurourol. Urodynam. 21:225\u2013230, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/nau.10043","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:25:36Z","timestamp":1030317936000},"page":"225-230","source":"Crossref","is-referenced-by-count":26,"title":["Role of supraspinal serotonin receptors for micturition in normal conscious rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Osamu","family":"Ishizuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baojun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Igawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikard","family":"Pehrson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Erik","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,3,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903590208"},{"issue":"232","key":"e_1_2_1_4_1","first-page":"5","article-title":"Evidence for the existence of monoamine\u2010 containing neurons in the central nervous system. 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