{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:40:02Z","timestamp":1700527202823},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,12,2]],"date-time":"2002-12-02T00:00:00Z","timestamp":1038787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims:<\/jats:title><jats:p>The objective of this study was to examine the effects of interferon\u2010gamma injection on changes in collagen content, after the creation of partial bladder outlet obstruction in the rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A total of 50 Sprague\u2010Dawley female rats were subjected to partial bladder outlet obstruction by using metal rods. The rats were divided into five groups (n\u2009=\u200910 in each group): normal control (N), sham operation (S), bladder outlet obstruction for 4 weeks (BOO), interferon\u2010gamma injection after sham operation (S\u2009+\u2009IFN), and interferon\u2010gamma injection after bladder outlet obstruction (BOO\u2009+\u2009IFN). Interferon\u2010gamma was subcutaneously injected (100,000 units per injection, LG chemical Co., Seoul, Korea) daily for 4 weeks in the injection groups, after which all rats were sacrificed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The collagen area percentage (collagen\/collagen\u2009+\u2009muscle) in each bladder, calculated through image analysis, was 40.7\u2009\u00b1\u20091.6% in the N, 38.2\u2009\u00b1\u20092.0% in the S, 26.6\u2009\u00b1\u20093.8% in the S\u2009+\u2009IFN, 19.9\u2009\u00b1\u20092.5% in the BOO, and 12.4\u2009\u00b1\u20092.0% in the BOO\u2009+\u2009IFN group (mean\u2009\u00b1\u2009standard error). The difference in the collagen area percentage between the N and S groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) was not significant, but there were significant differences between the N and S\u2009+\u2009IFN groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), between the S and S\u2009+\u2009IFN groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and between the BOO and BOO\u2009+\u2009IFN groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>It appears that interferon\u2010gamma decreases the collagen content in the obstructed rat bladder. Neurourol. Urodynam. 22:70\u201376, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.10072","type":"journal-article","created":{"date-parts":[[2002,12,12]],"date-time":"2002-12-12T14:10:39Z","timestamp":1039702239000},"page":"70-76","source":"Crossref","is-referenced-by-count":2,"title":["Morphometric analysis of the collagen changes induced by subcutaneous injection of interferon\u2010gamma after bladder outlet obstruction in the rat"],"prefix":"10.1002","volume":"22","author":[{"given":"Kwang Myung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeongyoon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Yun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56985-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-209-43886a"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.2.516"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12612819"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36650-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320105"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0885-4505(86)90124-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112945"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/archderm.1990.01670340047006","article-title":"A controlled trial of intralesional recombinant interferon\u2010gamma in the treatment of keloidal scarring","volume":"126","author":"Granstein RD","year":"1990","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37844-8"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(85)80033-9"},{"issue":"2","key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0022-5347(17)32685-X","article-title":"Loss of elasticity in dysfunctional bladders: urodynamic and histochemical correlation","volume":"152","author":"Landau EH","year":"1994","journal-title":"J Urol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210418"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)53503-X"},{"key":"e_1_2_1_16_1","first-page":"6","article-title":"Structure and function of the rabbit bladder altered by chronic obstruction or cystitis","volume":"14","author":"Mayo ME","year":"1976","journal-title":"Invest Urol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12286461"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00154-R"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.33.309"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199405000-00018"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2940761"},{"key":"e_1_2_1_22_1","first-page":"660","article-title":"Interferon gamma inhibits lipocyte activation and extracellular matrix mRNA expression during experimental liver injury: implications for treatment of hepatic fibrosis","volume":"42","author":"Rockey DC","year":"1994","journal-title":"J Invest Med"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65757-4"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49753-9"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.10072","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.10072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:10:42Z","timestamp":1700525442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.10072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,2]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/nau.10072"],"URL":"https:\/\/doi.org\/10.1002\/nau.10072","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,2]]}}}