{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:44:46Z","timestamp":1782978286830,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T00:00:00Z","timestamp":1067212800000},"content-version":"vor","delay-in-days":299,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this work, we are presenting a rat animal model for bladder hyperreflexia after suprasacral spinal cord transection. Our aim was to standardize an animal model that can be useful in studying this condition. After standardizing the animal model in a pilot study, 26 female Sprague\u2013Dawley rats were subjected to spinal cord transection at the level of T10 vertebra. Four animals were subjected to cystometrogram (CMG) 24 hr after spinalization and six rats 3 weeks post\u2010spinalization. These CMGs were compared to that of six normal controls. The detailed description of the model presented in this manuscript, is the final result after several modifications. All the animals consistently developed hyperreflexia after an initial period of spinal shock phase. Expressed volume of urine continued to decrease until it reached a plateau after peaking at 1\u2010week post\u2010spinalization. The attrition rate reached 27.3% after several improvements in the animal model and was mostly from self\u2010inflicted injuries. Post\u2010operative complications included hypothermia, decubitus ulcers, hematuria, urinary tract infection in addition to the unexplained death of two animals. In conclusion, we believe that this animal model closely resembles the clinical condition of hyperreflexia and follows similar course. The relative low cost of this animal model and the easy maintenance makes it a valuable tool to study such a condition. Neurourol. Urodynam. 22:693\u2013698, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/nau.10147","type":"journal-article","created":{"date-parts":[[2003,10,29]],"date-time":"2003-10-29T11:00:30Z","timestamp":1067425230000},"page":"693-698","source":"Crossref","is-referenced-by-count":21,"title":["Urinary bladder hyperreflexia: A rat animal model"],"prefix":"10.1002","volume":"22","author":[{"given":"Hassan","family":"Shaker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Sherif","family":"Mourad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Hatem","family":"Elbialy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Elhilali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61998-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66405-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.855934"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00212-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(90)90105-R"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65137-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307703"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902880303"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62138-4"},{"issue":"5","key":"e_1_2_1_11_1","first-page":"H2077","article-title":"Episodic hypertension due to autonomic dysreflexia in acute and chronic spinal cord\u2010injured rats","volume":"268","author":"Krassioukov AV","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1010"},{"key":"e_1_2_1_13_1","first-page":"410","article-title":"Electophysiological study of micturition reflexes in rats","volume":"257","author":"Malory B","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_1_14_1","first-page":"197A","article-title":"Electrophysiological analysis of the pontine micturition center in the rat","volume":"139","author":"Noto H","year":"1988","journal-title":"J Urol"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.2.421"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1998.15.375"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930140207"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62302-4"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00559.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(01)00137-4"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702041"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.1.R295"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)32574-0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00376-X"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00234-4"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00474-X"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.10147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.10147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T21:43:56Z","timestamp":1700516636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.10147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/nau.10147"],"URL":"https:\/\/doi.org\/10.1002\/nau.10147","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}