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Changes in muscle and connective tissue were assessed by unbiased, modern morphometry and biochemical analysis After obstruction the results were as follows: (1) a 6\u2010fold increase in bladder weight, (2) a 2.5\u2010fold increase in smooth muscle cell size, (3) a 3\u2010fold increase in smooth muscle cell number, (4) unchanged proportions between muscle and connective tissue, (5) unchanged hydroxyproline concentrations, (6) an 8\u2010fold increase in total collagen content, (7) an increase in the ratio of type I\/III collagen, and (8) a 7\u20108\u2010fold increase in total content of type I and III collagen. All changes were markedly, though incompletely, reversed after recovery, except smooth muscle cell number and the ratio of type I\/III collagen. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/nau.1930140308","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T13:12:51Z","timestamp":1173013971000},"page":"269-284","source":"Crossref","is-referenced-by-count":33,"title":["Morphological, stereological, and biochemical analysis of the mini\u2010pig urinary bladder after chronic outflow obstruction and after recovery from obstruction"],"prefix":"10.1002","volume":"14","author":[{"given":"K. K.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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