{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:52:50Z","timestamp":1780105970322,"version":"3.54.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T00:00:00Z","timestamp":1085356800000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the effects of 1\u2010(2\u2010pyrimidinyl)\u2010piperazine (1\u2010PP), a buspirone metabolite, on bladder function in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Micturition reflexes in the rat were evaluated in two models of bladder function; a constant infusion model employing 0.5% acetic acid and an isovolumic model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the constant infusion model, 1\u2010PP (0.14\u20131.32 mg\/kg) dose\u2010dependently and significantly decreased the number of bladder contractions measured during a 30 min recording period, with little effect on the pressure developed during each contraction. 1\u2010PP is an \u03b1<jats:sub>2<\/jats:sub>\u2010adrenergic receptor antagonist. The \u03b1<jats:sub>2<\/jats:sub> antagonists BRL44408 (\u03b1<jats:sub>2A<\/jats:sub> vs. \u03b1<jats:sub>2B<\/jats:sub> selective; 0.3 and 1 mg\/kg), imiloxan (\u03b1<jats:sub>2B<\/jats:sub> vs. \u03b1<jats:sub>2A<\/jats:sub> selective; 1 mg\/kg), and yohimbine (non\u2010subtype selective; 1 mg\/kg; but not 0.3 mg\/kg) also significantly reduced the number of contractions. Vehicle was without effect. In the isovolumic model, 1\u2010PP (0.03\u20131.0 mg\/kg) produced a dose\u2010dependent and significant reduction in the number of bladder contractions recorded during a 15 min assessment period, with the maximum effect observed at 0.3 mg\/kg. 1\u2010PP had little effect on blood pressure; the only effect was observed at the highest dose (1 mg\/kg) where it produced a transient 17% decrease in pressure. Cromakalim and tolterodine served as comparitors in all studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>1\u2010PP decreased the number of bladder contractions evoked by the micturition reflex at doses that had little effect on either the pressure developed during each bladd er contraction or on blood pressure. The effects of 1\u2010PP are likely mediated primarily by \u03b1<jats:sub>2<\/jats:sub> receptor antagonism. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20037","type":"journal-article","created":{"date-parts":[[2004,5,25]],"date-time":"2004-05-25T07:02:27Z","timestamp":1085468547000},"page":"709-715","source":"Crossref","is-referenced-by-count":12,"title":["1\u2010(2\u2010pyrimidinyl)\u2010piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat"],"prefix":"10.1002","volume":"23","author":[{"given":"Robert A.","family":"Myers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jane","family":"Plym","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Signor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Lodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1983.tb08810.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.691"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01543-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69062616.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65552-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00572.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.60.363"},{"key":"e_1_2_1_9_1","first-page":"181","article-title":"Involvement of 5\u2010Hydroxytryptamine 1A receptors in the modulation of micturition reflexes in the anesthetized rat","volume":"262","author":"Lecci A","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40111-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00488-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb12968.x"},{"key":"e_1_2_1_13_1","first-page":"1192","article-title":"S18616, a highly potent, spiromidazoline agonist at \u03b12\u2010adrenoceptors: I: receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine","volume":"295","author":"Millan MJ","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005243"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)89661-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00333-2"},{"key":"e_1_2_1_17_1","first-page":"1258","article-title":"Effects of several 5\u2010hydroxytrptamine1A receptor ligands on the micturition reflex in rats: Comparison with WAY 100635","volume":"290","author":"Testa R","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.10.1.65"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930110509"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-5347(17)42448-7","article-title":"Contraction of urinary bladder by central norepinephrine originating in the locus coeruleus","volume":"139","author":"Yoshimura N","year":"1998","journal-title":"J Urol"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90801-7"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.036798"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20037","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T17:17:10Z","timestamp":1700500630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/nau.20037"],"URL":"https:\/\/doi.org\/10.1002\/nau.20037","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}