{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:05:34Z","timestamp":1784253934471,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T00:00:00Z","timestamp":1103155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Donepezil hydrochloride, a central cholinergic drug, is widely used for improving cognitive decline in Alzheimer's disease (AD). We investigated whether donepezil might affect the lower urinary tract (LUT) function in AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Alzheimer's Disease Assessment Scale cognitive subscale (ADAS\u2010cog) (0\u201370, increase as impairment), urinary questionnaire, and electromyography (EMG)\u2010cystometry were performed in eight patients with AD before and after treatment with 5 mg\/day of donepezil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The first assessment (before donepezil) showed moderate cognitive decline in the patients as a mean ADAS\u2010cog score of 27.0 (range: 17\u201335) (normal &lt;\u200915). Seven patients had urinary symptoms including urinary urgency incontinence in five.EMG\u2010cystometry revealed neurogenic detrusor overactivity in seven with a mean detrusor pressure of 44.9 cmH<jats:sub>2<\/jats:sub>O (20\u2013101), mean bladder capacity of 202 ml (20\u2013412), and post\u2010void residuals in none. The second assessment (3 months after donepezil) showed a decrease in the ADAS\u2010cog score to 23.3 (11\u201335) though without statistical significance. Urinary incontinence disappeared in one and none had a new onset of incontinence. EMG\u2010cystometry revealed an increase in the detrusor pressure on overactivity to 54.1 cmH<jats:sub>2<\/jats:sub>O (20\u2013122), but also an increase in the bladder capacity to 234 ml (80\u2013400), and post\u2010void residuals in one (40 ml).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the number of our patients was small, it seems possibly that donepezil could ameliorate cognitive function without serious adverse effects on the LUT function in patients with AD. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20102","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T19:18:13Z","timestamp":1103224693000},"page":"273-275","source":"Crossref","is-referenced-by-count":18,"title":["Preliminary communication: Urodynamic assessment of donepezil hydrochloride in patients with Alzheimer's disease"],"prefix":"10.1002","volume":"24","author":[{"given":"Ryuji","family":"Sakakibara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuharu","family":"Yoshiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Yamanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamichi","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_1_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-6738-1_1"},{"key":"e_1_2_1_5_1","first-page":"675","article-title":"MR imaging of the aging brain; pacthy white\u2010matter lesions and dementia","volume":"6","author":"Brant\u2010Zawadzki M","year":"1985","journal-title":"AJNR"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017126"},{"key":"e_1_2_1_7_1","first-page":"227","volume-title":"Neurophysiology of micturition and its modification in animal models of human disease, in the autonomic nervous system: Nervous control of the urogenital system, vol 3","author":"de Groat WC","year":"1993"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182663"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02588-5"},{"key":"e_1_2_1_9_1","first-page":"539","article-title":"Central muscarinic mechanism of bladder overactivity associated with Alzheimer type senile dementia","volume":"4","author":"Komatsu K","year":"2000","journal-title":"Neurourol Urodyn"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901053200101"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.1.136"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.11.1356"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.5.658"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(01)00295-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.3.408"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.1994.tb00060.x"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T19:25:19Z","timestamp":1700508319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,16]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1002\/nau.20102"],"URL":"https:\/\/doi.org\/10.1002\/nau.20102","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,16]]}}}