{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:33:07Z","timestamp":1758817987933},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,9,19]],"date-time":"2005-09-19T00:00:00Z","timestamp":1127088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine if tamsulosin treatment prevents or decreases the incidence and severity of outlet obstruction\u2010induced bladder dysfunction in rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Male New Zealand White rabbits were treated with tamsulosin or vehicle for 4 weeks with treatments initiated 1 week prior to sham or obstruction surgery. Cystometry was done on anesthetized rabbits 21 days after surgery. The bladders were then removed, weighed, and prepared for in vitro whole bladder studies. Responses to 32 Hz field stimulation (FS), carbachol, phenylephrine, and KCl were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obstruction resulted in a significant increase in bladder weight, which was unchanged by tamsulosin treatment and a significant increase in micturition pressure in the vehicle\u2010treated group but not in the tamsulosin\u2010treated group. Compliance was significantly decreased in both obstructed groups. The vehicle\u2010treated obstructed rabbits had a very sharp increase in intravesical pressure as the bladder reached capacity; this was not seen in the tamsulosin\u2010treated obstructed rabbits. Tamsulosin did not change the pattern of modifications in contractile responses induced by bladder outlet obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In vitro responses of vehicle and tamsulosin\u2010treated obstructed rabbit groups in this study were similar. A greater micturition pressure was found for the vehicle\u2010treated obstructed group than for the tamsulosin\u2010treated obstructed group, which was probably due to decreased urethral resistance in the latter. On a functional basis, the higher compliance at capacity and decreased micturition pressure in the tamsulosin\u2010treated obstructed group would be considered beneficial for bladder function. Neurourol. 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Calcium dysregulation in bladder power generation and the ability to perform work","volume":"184","author":"Levin RM","year":"1997","journal-title":"Scand J Urol Nephrol"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-8266(00)00115-4"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00472-2"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00333-9"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(82)90127-3"},{"key":"e_1_2_1_19_1","first-page":"90","article-title":"Decrease of ultrasound estimated bladder weight during tamsulosin treatment in patients with benign prostatic enlargement","volume":"74","author":"Sironi D","year":"2002","journal-title":"Arch Ital Urol Androl"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.51.5.764"},{"key":"e_1_2_1_21_1","first-page":"1159","volume-title":"Adult and pediatric urology","author":"Zderic SA","year":"1996"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20150","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T02:53:11Z","timestamp":1700535191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,19]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/nau.20150"],"URL":"https:\/\/doi.org\/10.1002\/nau.20150","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,19]]}}}