{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:15:52Z","timestamp":1791090952147,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T00:00:00Z","timestamp":1135123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>In a rat model, intravesical oxybutynin was recently shown to suppress pelvic afferent nerves. This study evaluates if a similar effect exists after systemic administration of oxybutynin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four single afferent bladder nerves were identified in 15 rats. Based on their conduction velocities they were grouped as C or A\u03b4 fibers. Bladder filling parameters and afferent nerve spike rate were simultaneously recorded 30 min before administration of saline (nine fibers) or oxybutynin (15 fibers, 1 mg\/kg), and again 30, 60, 90, 120, and 150 min after systemic saline or drug administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No change in C or A\u03b4 afferent spike rate was observed after saline injection (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.90). In the study group, a decrease in afferent activity was noted after systemic administration of oxybutynin for C fibers, which were statistically significant 90 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.004) and 120 min (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.028) after drug delivery. After 150 min, the spike rate was still lower compared to the baseline filling, without reaching the level of significance (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.09). For the A\u03b4 fibers the decrease in afferent spike rate was already significant at 30 min (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005) and remained significant during all subsequent fillings (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.012). To avoid a possible confounding influence of the bladder compliance, which increased significantly after injection of oxybutynin (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.011), afferent activity during bladder filling was recalculated. Normalized afferent sensitivity of C and A\u03b4 fibers decreased significantly after injection of oxybutynin. This means that the decrease in afferent spike rate is not the result of an increased compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this study strongly suggest that oxybutynin directly or indirectly influences bladder sensory nerves, inhibiting the afferent part of the micturition reflex. Neurourol Urodynam. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20208","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T18:16:32Z","timestamp":1135188992000},"page":"156-161","source":"Crossref","is-referenced-by-count":88,"title":["Systemic oxybutynin decreases afferent activity of the pelvic nerve of the rat: New insights into the working mechanism of antimuscarinics"],"prefix":"10.1002","volume":"25","author":[{"given":"Kevin","family":"De Laet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"De Wachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Wyndaele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00622-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2003"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00056.2003"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01803-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.08.063"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000049903.60057.4b"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.503bb.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342140-00004"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703068"},{"key":"e_1_2_1_11_1","first-page":"867","article-title":"R and S enantiomers of oxybutynin: Pharmacological effects in guinea pig bladder and intestine","volume":"247","author":"Kachur JF","year":"1988","journal-title":"J Pharmacol Ther"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.11.021"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(2000)19:1<87::AID-NAU9>3.0.CO;2-O"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01535-2"},{"key":"e_1_2_1_15_1","first-page":"586","article-title":"The anticholinergic activity of agents indicated for urinary incontinence is an important property for effective control of bladder dysfunction","volume":"251","author":"Noronha\u2010Blob L","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_16_1","first-page":"F1082","article-title":"Dissociation of urinary kallikrein activity and salt and water excretion in the rat","volume":"250","author":"Pollock DM","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.5.2420"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)80012-W"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05670.2001"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1996)15:5<513::AID-NAU8>3.0.CO;2-I"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199506030-00007"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.11.003"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.1997.tb00156.x"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T02:45:29Z","timestamp":1700534729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,21]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1002\/nau.20208"],"URL":"https:\/\/doi.org\/10.1002\/nau.20208","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,21]]}}}