{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:59:22Z","timestamp":1761742762303},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T00:00:00Z","timestamp":1146614400000},"content-version":"vor","delay-in-days":122,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>\u03b11\u2010blockers improve voiding symptoms through the reduction of prostatic and urethral smooth muscle tone; however, the underlying mechanism of improvement of storage symptoms is not known. Using a rat model of detrusor overactivity caused by cerebral infarction (CI), we undertook the present study to determine whether the effect of an \u03b11\u2010blocker, naftopidil, is dependent on the suppression of C\u2010fiber afferents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To induce desensitization of C\u2010fiber bladder afferents, we injected resiniferatoxin (0.3 mg\/kg, RTX) sub\u2010cutaneously to female Sprague\u2010Dawley rats 2 days prior to left middle cerebral artery occlusion (MCAO) (RTX\u2010CI rats). As controls we used rats without RTX treatment (CI rats). MCAO and insertion of a polyethylene catheter through the bladder dome were performed under halothane anesthesia. We investigated the effects on cystometrography (CMG) of intravenous (i.v.), intracerebroventricular (i.c.v.), or intrathecal (i.t.) administration of naftopidil in conscious CI rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bladder capacity (BC) was markedly reduced after MCAO in both RTX\u2010CI and CI rats. I.v. administration of naftopidil significantly increased BC in CI rats without an increase in residual volume, but it had no effects on BC in RTX\u2010CI rats. I.t. administration of naftopidil significantly increased BC in CI but not in RTX\u2010CI rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that naftopidil has an inhibitory effect on C\u2010fiber afferents in the lumbosacral spinal cord, improving BC during the storage phase. Neurourol. Urodynam. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20253","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T19:22:49Z","timestamp":1146684169000},"page":"461-467","source":"Crossref","is-referenced-by-count":36,"title":["Improvement of bladder storage function by \u03b11\u2010blocker depends on the suppression of C\u2010fiber afferent activity in 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