{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T14:10:26Z","timestamp":1736518226942,"version":"3.32.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T00:00:00Z","timestamp":1151366400000},"content-version":"vor","delay-in-days":177,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To test the efficacy of WAY\u2010133537 for the treatment of overactive bladder (OAB) in a chronic paraplegic rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010eight female Sprague\u2013Dawley rats were used in this study. Six animals served as normal controls (without spinal cord transaction (ST)), while 42 rats underwent ST at the 10th thoracic vertebra. Two weeks after ST, cystometrogram (CMG) was performed in six randomly chosen animals to ensure the development of neurogenic detrusor overactivity. The remaining 36 rats were divided into three equal groups, 12 received the vehicle as \u201cparaplegic controls,\u201d 12 received WAY\u2010133537 0.3 mg\/kg, and 12 received WAY\u2010133537 3 mg\/kg. Each \u201cparaplegic control\u201d and treatment group was further divided into two sub\u2010groups (n\u2009=\u20096), with CMG at 3 and 4 weeks after ST, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two weeks after ST, all \u201cvehicle control\u201d rats developed detrusor overactivity with a mean frequency of 0.96 and 1.48 contractions\/min and amplitude of 22.96 and 31.22 cm H<jats:sub>2<\/jats:sub>O with 1\u2010 and 2\u2010week treatment, respectively. Neurogenic detrusor overactivity disappeared from 50% of rats that received WAY\u2010133537 0.3 mg\/kg for 1 week, and frequency decreased to 0.41 contractions\/min. After 2 weeks of treatment, detrusor overactivity vanished from 67% of the animals with even further reduction in the frequency of detrusor overactivity (0.22 contractions\/min,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In rats that received 3 mg\/kg of the drug for 1 week, detrusor overactivity disappeared from only one animal with a non\u2010significant decline in frequency. Fifty percent of rats given WAY\u2010133537 at the dose of 3 mg\/kg\/day for 2 weeks manifested no detrusor overactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WAY\u2010133537 shows efficacy in increasing bladder capacity and reducing the frequency of spontaneous bladder contractions after ST in rats without decreasing voiding pressure. Neurourol. 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