{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:15:52Z","timestamp":1791090952080,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,31]],"date-time":"2007-01-31T00:00:00Z","timestamp":1170201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To test whether nerve growth factor (NGF) concentration in human bladder urothelium\/suburothelium is related to detrusor overactivity (DO), bladder sensation, detrusor contractility, or other aspects of lower urinary tract function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Concentration of NGF was measured (using ELISA) in superficial bladder biopsies from 27 women (mean age 52 years, range 22\u201382) after comprehensive videourodynamics and bladder diary. Approximately half (12\/27) showed clear DO and half did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no evidence for increased NGF concentration in subjects with DO (association negative by Mann\u2013Whitney test, <jats:italic>P<\/jats:italic>\u2009=\u20090.23). NGF was not significantly associated with two measures of detrusor contractility (Spearman's r\u2009=\u2009\u22120.29, <jats:italic>P<\/jats:italic>\u2009=\u20090.17; r\u2009=\u2009\u22120.20, <jats:italic>P<\/jats:italic>\u2009=\u20090.33); nor with four measures inversely related to sensation: volume at strong desire to void and maximum capacity on cystometry (r\u2009=\u2009\u22120.13, <jats:italic>P<\/jats:italic>\u2009=\u20090.53; r\u2009=\u2009\u22120.23, <jats:italic>P<\/jats:italic>\u2009=\u20090.28), and maximum voided volume and mean daytime voided volume on bladder diary (r\u2009=\u2009\u22120.29, <jats:italic>P<\/jats:italic>\u2009=\u20090.16; r\u2009=\u2009\u22120.16, <jats:italic>P<\/jats:italic>\u2009=\u20090.44). It was significantly associated with 24\u2010hr urine output on bladder diary (Spearman's r\u2009=\u2009\u22120.55, <jats:italic>P<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated NGF levels in human urothelium\/suburothelium are not strongly associated with DO, detrusor contractility or increased bladder sensation. NGF levels are lower in subjects with higher 24\u2010hr urine output. This observation is consistent with a role for NGF in an active process (trafficking) involved in bladder filling. Neurourol. Urodynam. 26:405\u2013409, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20372","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T04:33:10Z","timestamp":1170477190000},"page":"405-409","source":"Crossref","is-referenced-by-count":51,"title":["Role of urothelial nerve growth factor in human bladder function"],"prefix":"10.1002","volume":"26","author":[{"given":"Lori A.","family":"Birder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Wolf\u2010Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Resnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00061-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2004.01.001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)91065-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018117"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.2.395"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200006)183:3<289::AID-JCP1>3.0.CO;2-6"},{"key":"e_1_2_1_8_2","unstructured":"GiannantoniA NardicchiV MacchionniL et al.2004a.Nerve growth factor bladder tissue levels in patients with neurogenic detrusor overactivity before and after botulinum\u2010A toxin injections into the detrusor muscle. 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