{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:07:32Z","timestamp":1788955652468,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T00:00:00Z","timestamp":1172620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess and compare the efficacy of botulinum\u2010A toxin (BTX\u2010A) injections into the detrusor in idiopathic and neurogenic detrusor overactivity (IDO and NDO) resistant to anticholinergic treatment with respect to patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>In a prospective study, 16 patients with IDO and 14 with NDO resistant to anticholinergic treatment were injected with 500 U of Dysport\u00ae into the detrusor. Clinical, urodynamic, and satisfaction assessments were performed at baseline and after BTX\u2010A injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In IDO as well as in NDO, there was a significant increase in median maximum cystometric capacity (MCC) from 177.5 to 262.5 ml (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005) and 160 to 270 ml (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), median bladder compliance from 24.5 to 40.0 ml\/cmH<jats:sub>2<\/jats:sub>O (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005) and 25.5 to 44.0 ml\/cmH<jats:sub>2<\/jats:sub>O (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and median PVR from 15 to 80 ml (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and 15.0 to 62.5 ml (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), respectively. Median <jats:italic>P<\/jats:italic><jats:sub>det max<\/jats:sub> decreased significantly from 49 to 37 cmH<jats:sub>2<\/jats:sub>O (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005) and 48.5 to 37.0 cmH<jats:sub>2<\/jats:sub>O (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), and median P<jats:sub>det<\/jats:sub> Q<jats:sub>max<\/jats:sub> from 32.0 to 20.0 ml\/sec (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005) and 36.0 to 21.5 ml\/sec (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), respectively. The effect of BTX\u2010A injections lasted for a median time of 5 months in both groups. Median daytime frequency, nocturia, and number of used pads decreased significantly in both groups. More than 80% of the patients were satisfied with the effect of BTX\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with intractable IDO respond to intradetrusor BTX\u2010A with a significant and comparable but temporally limited effect in urodynamic and LUTS parameters as those with NDO. The majority of patients were satisfied with treatment. Neurourol. 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