{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:08:37Z","timestamp":1761764917374},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T00:00:00Z","timestamp":1181606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>A method was developed and evaluated to simultaneously register intraabdominal pressure (IAP) and intravesical pressure (IVP) during cystometry in conscious rats. In addition, IAP and IVP were recorded in rats with experimental detrusor overactivity (DO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sprague Dawley rats (n\u2009=\u200924) were used. Six female rats were subjected to partial bladder outlet obstruction for 2 weeks. A catheter was implanted into the bladder to record the IVP, and a balloon\u2010fitted catheter was positioned in the abdominal cavity to record the IAP. PGE<jats:sub>2<\/jats:sub> was given intravesically to induce DO. Detrusor pressure (DP) was defined as the IVP corrected for IAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recorded as increases in IAP, all rats of both sexes exhibited abdominal straining during every void. In controls, a maximal IAP of 6.0\u2009\u00b1\u20091.4 cmH<jats:sub>2<\/jats:sub>O (range 3\u201315 cmH<jats:sub>2<\/jats:sub>O) was registered (n\u2009=\u200912) at the time of the flow pressure (FP). Intravesical administration of PGE<jats:sub>2<\/jats:sub> or BOO did not affect the IAP at basal pressure, FP or micturition pressure. Changes in IAP due to movement or non\u2010voiding\u2010related straining were subtracted from IVP to generate DP and to visualize DO after BOO or intravesical PGE<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The conscious rat uses abdominal straining during voiding, and maximal IAP is recorded at the onset of urinary flow. Simultaneous registration of IAP and IVP during the micturition cycle in conscious rats is a convenient method for accurate quantification of pressures inside the bladder and for studying \u201ctrue\u201d DO without interference from movement artifacts. Neurourol. Urodynam. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20460","type":"journal-article","created":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T16:47:39Z","timestamp":1181666859000},"page":"88-95","source":"Crossref","is-referenced-by-count":50,"title":["Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats\u2014Effects of bladder outlet obstruction and intravesical PGE<sub>2<\/sub>"],"prefix":"10.1002","volume":"27","author":[{"given":"Tack","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Erik","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomi","family":"Streng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petter","family":"Hedlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01196-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01768-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00439-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00238-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10086"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20043"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00556.2005"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00088.2005"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02567-0"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T01:49:22Z","timestamp":1700531362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,12]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/nau.20460"],"URL":"https:\/\/doi.org\/10.1002\/nau.20460","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,12]]}}}