{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:41Z","timestamp":1786978241211,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate whether vaginal estrogen cream combined with tolterodine is more effective than tolterodine alone in the treatment of postmenopausal women with overactive bladder (OAB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This is an unblinded study without placebo. A preliminary study consisted of tolterodine 2 mg twice per day for 3 months had been conducted for 25 postmenopausal women with OAB. Over a period of 11 months, 80 postmenopausal women with OAB underwent a prospective randomized trial. These patients were equally randomized into two groups. The interventions for the 12\u2010week treatment period included 2 mg tolterodine twice per day for the group A and 2 mg tolterodine twice per day\/vaginal conjugated equine estrogen 0.625 mg twice a week for the group B. Identical pre\u2010 and post\u2010treatment assessments included bladder diary, Urogenital Distress Inventory\u20106 (UDI\u20106), and Incontinence Impact Questionnaire\u20107 (IIQ\u20107).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 80 women (65.2 years, range 58\u201373) completed this study. The between groups comparison showed that the group B had significant improvements in mean daytime frequency and voided volume after treatment (14.8\u20135.8 vs. 14.1\u20136.4, P\u2009=\u20090.001 and 115.8\u2013141.9 vs. 108.5\u2013134.5, P\u2009=\u20090.007, respectively). Additionally, a comparison of the final total scores of UDI\u20106 and IIQ\u20107 between the two groups revealed that the group B had a statistically significant improvement in quality of life than that in the group A (8.6\u20136.9 vs. 9.5\u20137.2, P\u2009&lt;\u20090.001 and 9.4\u20136.1 vs. 10.2\u20136.5, P\u2009&lt;\u20090.001, respectively). Changes in the other symptoms, including nocturia, urgency and urge incontinence, were not statistically significant but actually achieved improved in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A combination of vaginal estrogen cream and tolterodine is a potential therapy for postmenopausal women with OAB. Neurourol. Urodynam. 28:47\u201351, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.20583","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T18:35:28Z","timestamp":1229625328000},"page":"47-51","source":"Crossref","is-referenced-by-count":75,"title":["Randomized comparison of tolterodine with vaginal estrogen cream versus tolterodine alone for the treatment of postmenopausal women with overactive bladder syndrome"],"prefix":"10.1002","volume":"28","author":[{"given":"Ling\u2010Hong","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Lung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Kuei","family":"Soong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Keith","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yet\u2010Jane","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10010"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032662"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00622-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003193.pub3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.01.006"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01052.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1026219"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(92)90059-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610120059941"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200101000-00023"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00676-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50203.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10167"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000148645.93603.62"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.06.042"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70243-0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000140502.34334.75"},{"key":"e_1_2_1_20_2","first-page":"129","volume-title":"Statistical methods","author":"Snedecor WG","year":"1980"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64567-3"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00437-8"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02228.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000052504"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(00)00143-2"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20110"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66326-4"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20583","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T18:49:30Z","timestamp":1700506170000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,16]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/nau.20583"],"URL":"https:\/\/doi.org\/10.1002\/nau.20583","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,16]]}}}