{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:34:31Z","timestamp":1768314871314,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T00:00:00Z","timestamp":1213228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We examined the relation between the loss of bladder function during obstruction and the potential for recovery of function after de\u2010obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Guinea pigs received a partial urethral obstruction. Bladder pressure, urine flow rate, detrusor overactivity (DO), compliance and contractility were examined weekly for 2\u20134 weeks (short), 6\u20138 weeks (medium), or 9\u201312 weeks (long). Then the obstruction was removed and bladder function followed up to 7 weeks. The groups were compared to animals receiving only obstruction or a sham operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During obstruction the three de\u2010obstruction groups and the obstruction group progressively lost bladder function. Flow rate remained stable, compliance decreased, pressure, contractility and DO increased. After de\u2010obstruction the response in the three de\u2010obstruction groups varied. In S, bladder pressure and compliance normalized, contractility initially increased then decreased towards high normal values, DO remained high normal and flow rate increased. In M, bladder pressure and DO decreased to above average normal levels. Compliance improved but did not normalize. Contractility initially stabilized, then decreased to just above the normal range. Flow\u2010rate increased. In L, bladder pressure and DO decreased to high normal. Compliance did not improve. Contractility decreased directly after de\u2010obstruction, stabilizing at an above normal level, flow\u2010rate increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The potential for functional recovery decreases with increasing loss of bladder function. At all stages of bladder dysfunction, voiding pressure appears to normalize after de\u2010obstruction. However, contractility remains high and compliance low. Such a bladder may be more vulnerable to new events of outflow obstruction than a low contractile, normal compliant bladder. Neurourol. Urodynam. 27:782\u2013788, 2008, \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20588","type":"journal-article","created":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T19:47:24Z","timestamp":1213300044000},"page":"782-788","source":"Crossref","is-referenced-by-count":8,"title":["Potential for recovery in bladder function after removing a urethral obstruction"],"prefix":"10.1002","volume":"27","author":[{"given":"K.P.","family":"Wolffenbuttel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.W.D.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Scheepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.J.","family":"Kok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65796-5"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"Bladder dysfunction in boys with posterior urethral valves","volume":"188","author":"Holmdahl G","year":"1997","journal-title":"Scand J Urol Nephrol"},{"key":"e_1_2_1_4_2","first-page":"66","article-title":"Early primary valve ablation for posterior urethral valves","volume":"5","author":"Mitchell ME","year":"1966","journal-title":"Semin Pediatr Surg"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000084142.71123.b5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.07.009"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.06.008"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.01.019"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.02.006"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.11.002"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1021"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67241-2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65920-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65075-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66342-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)69006-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.07.050"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199502000-00058"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65553-8"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2005.11.015"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0022-5347(17)50253-0","article-title":"Smooth muscle cell hypertrophy and hyperplasia in the rat detrusor after short\u2010time infravesical outflow obstruction","volume":"131","author":"Uvelius B","year":"1984","journal-title":"J Urol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61783-X"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000139986.08972.e3"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66502-9"},{"key":"e_1_2_1_25_2","first-page":"32","article-title":"Animal models of bladder outlet obstruction and molecular insights into the basis for the development of bladder dysfunction","volume":"32","author":"Buttyan R","year":"1997","journal-title":"Eur Urol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115488"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.5.C1247"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00131.2002"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.503bb.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.06.064"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930120610"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930120308"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.260.5.C1085"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365599109024556"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"13873","DOI":"10.1016\/S0021-9258(18)80081-3","article-title":"Cloning and expression of a smooth muscle caldesmon","volume":"264","author":"Bryan J","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00513.2002"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004410000262"},{"key":"e_1_2_1_38_2","first-page":"302","article-title":"Regional alterations in the expression of smooth muscle myosin isoforms in response to partial bladder outlet obstruction","volume":"2005","author":"Mannikarottu AS","journal-title":"J Urol"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6777(2000)19:6<701::AID-NAU8>3.0.CO;2-W"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FPE03002X"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.2006.00393.x"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40633-1"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1992.tb15791.x"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.03.011"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008880410015336"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-2031(03)00047-X"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07046.x"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20094"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.11.016"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66585-8"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00609-3"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40114-5"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20588","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T01:31:20Z","timestamp":1700530280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,12]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1002\/nau.20588"],"URL":"https:\/\/doi.org\/10.1002\/nau.20588","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,12]]}}}