{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:06:41Z","timestamp":1700543201227},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T00:00:00Z","timestamp":1213228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The objective of this study was to test a custom device aimed at increasing repeatability of abdominal leak point pressure (LPP) measurements in rodents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The device consisted of a soft\u2010tipped force applicator with a force sensor which was moved in the vertical direction by a linear actuator, laser crosshairs for accurate positioning, and a hand\u2010held wired remote control system. One expert and two novice experimenters acquired LPP measurements using manual and device methods by applying a gradually increasing force with the finger or the device, respectively, until a leak was visually observed at the urethral meatus. The device was tested at fast, medium, and slow speeds. A leak sensor was also tested to determine presence of a leak and reaction time of the user. The change in bladder pressure due to the externally applied force (LPP) was the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in mean LPP value when compared across experiments (expert, novice), method (manual, device), or speeds. The pooled variance of LPP was significantly decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) compared to the manual method when using the device at medium speed; however the slower speed showed no further improvement over the medium speed. The wet sensor detected leaks 385\u2009\u00b1\u2009187 msec earlier than users' reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of the device can decrease variability of the experiment but does not alter mean values. Reaction time, inherent in both the manual and device methods, has the potential for a significant impact on LPP outcomes. Neurourol. Urodynam. 27:553\u2013558, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20591","type":"journal-article","created":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T19:47:49Z","timestamp":1213300069000},"page":"553-558","source":"Crossref","is-referenced-by-count":9,"title":["Development of a device to standardize leak point pressure experiments in rats"],"prefix":"10.1002","volume":"27","author":[{"given":"Andrew J.","family":"Shoffstall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Zaszczurynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot S.","family":"Damaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02243-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001920070021"},{"key":"e_1_2_1_4_2","first-page":"CR345","article-title":"Urodynamic findings in female patients with urinary incontinence with intrinsic sphincteric deficiency","volume":"12","author":"Vecchioli\u2010Scaldazza C","year":"2006","journal-title":"Med Sci Monit"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00136-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000079492.09716.43"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00760.2004"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-004-1263-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01182-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00784.2006"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002400050064"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2002.02918.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20339"},{"key":"e_1_2_1_14_2","first-page":"109","article-title":"The short\u2010term timecourse of bilateral pudendal nerve injury on leak point pressure in female rats","volume":"42","author":"Ahn H","year":"2005","journal-title":"J Rehabil Res Dev"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000138476.42556.b8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000154342.75020.05"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20591","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T01:44:26Z","timestamp":1700531066000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,12]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1002\/nau.20591"],"URL":"https:\/\/doi.org\/10.1002\/nau.20591","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,12]]}}}