{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:41:16Z","timestamp":1790869276194,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,11,25]],"date-time":"2008-11-25T00:00:00Z","timestamp":1227571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To explore possible changes in expression and\/or function of \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010 and \u03b2\u2010adrenoceptor subtypes as a cause for bladder dysfunction in a rat model of bladder outlet obstruction (BOO).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      BOO was induced in rats by partial urethral ligature. Contraction and relaxation experiments were performed with isolated bladder strips from BOO, sham\u2010operated and non\u2010operated (control) rats 7 days after BOO induction. mRNA expression of \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010 and \u03b2\u2010adrenoceptor subtypes was assessed by quantitative real\u2010time PCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Receptor\u2010independent contraction or relaxation did not differ between BOO and sham rats. The \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010agonists methoxamine and A\u201061,603 caused only weak contraction without major differences between groups. Against KCl\u2010induced tone, the \u03b2\u2010adrenoceptor agonists noradrenaline and isoprenaline caused similar relaxation in BOO and sham rats, whereas relaxation in response to the \u03b2\n                      <jats:sub>3<\/jats:sub>\n                      \u2010selective BRL 37,344 was attenuated. Against passive tension, noradrenaline induced relaxation in sham and control rats; in contrast, noradrenaline induced contraction at low concentrations and relaxation at high concentrations in BOO rats. The contraction component was abolished by the \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010antagonist prazosin. The mRNA expression of \u03b1\n                      <jats:sub>1D<\/jats:sub>\n                      \u2010adrenoceptors was increased in BOO, whereas none of the other receptor mRNAs were up\u2010regulated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In a rat BOO model, weak contraction responses to \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010agonists and relaxation responses to \u03b2\u2010agonists are not altered to a major extent. Nevertheless, relaxation responses to the endogenous agonist noradrenaline are turned into \u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010adrenoceptor\u2010mediated contraction responses in BOO, possibly due to an up\u2010regulation of \u03b1\n                      <jats:sub>1D<\/jats:sub>\n                      \u2010adrenoceptors. Neurourol. Urodynam. 28:349\u2013355, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.20642","type":"journal-article","created":{"date-parts":[[2008,11,25]],"date-time":"2008-11-25T11:54:24Z","timestamp":1227614064000},"page":"349-355","source":"Crossref","is-referenced-by-count":41,"title":["The effect of bladder outlet obstruction on \u03b1\n                    <sub>1<\/sub>\n                    \u2010 and \u03b2\u2010adrenoceptor expression and function"],"prefix":"10.1002","volume":"28","author":[{"given":"Maurits M.","family":"Barendrecht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elfaridah P.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Vrydag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid 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