{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:35:41Z","timestamp":1769913341192,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T00:00:00Z","timestamp":1236038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the prevalence and mechanism of urinary dysfunction in GBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Urinary symptoms were observed and neurological examinations made repeatedly during hospitalization of 65 consecutive patients with clinico\u2010neurophysiologically definite GBS. The patients included 41 men, 24 women; mean age, 41 years old; mean Hughes motor grade, 3; AIDP, 28, AMAN, 37. Urodynamic studies consisted of uroflowmetry, measurement of post\u2010micturition residuals, medium\u2010fill water cystometry, and external anal sphincter electromyography. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Urinary dysfunction was observed in 27.7% of GBS cases (urinary retention, 9.2%). Urinary dysfunction was related to the Hughes motor grade (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), defecatory dysfunction (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and negatively related to serum IgG class anti\u2010ganglioside antibody GalNAc\u2010GD1a (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Urinary dysfunction was more common in AIDP (39%) than in AMAN (19%). No association was found between antibody titer against neuronal nicotinic acetylcholine receptors and urinary dysfunction. Urodynamic studies in nine patients, mostly performed within 8 weeks after disease onset, revealed post\u2010void residual in 3 (mean 195 ml), among those who were able to urinate; decreased bladder sensation in 1; detrusor overactivity in 8; low compliance in 1; underactive detrusor in 7 (both overactive and underactive detrusor in 5); and nonrelaxing sphincter in 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our series of GBS cases, 27.7% of the patients had urinary dysfunction, including urinary retention in 9.2%. Underactive detrusor, overactive detrusor, and to a lesser extent, hyperactive sphincter are the major urodynamic abnormalities. The underlying mechanisms of urinary dysfunction appear to involve both hypo\u2010 and hyperactive lumbosacral nerves. Neurourol. Urodynam. 28:432\u2013437, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20663","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T21:07:46Z","timestamp":1236114466000},"page":"432-437","source":"Crossref","is-referenced-by-count":42,"title":["Prevalence and mechanism of bladder dysfunction in Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1002","volume":"28","author":[{"given":"Ryuji","family":"Sakakibara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Awa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Vernino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Kishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm004"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-007-0022-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67665-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.8.1194"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.5.649"},{"key":"e_1_2_1_8_2","first-page":"586","article-title":"Double\u2010blind trial of intravenous methylprednisolone in Guillain\u2010Barr\u00e9 syndrome","volume":"341","author":"Guillain\u2010Barr\u00e9 syndrome steroid trial group","year":"1993","journal-title":"Lancet"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.3.597"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00088-6"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(03)00013-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20762"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10478"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0094-0143(21)00968-X","article-title":"Principles and clinical application of advanced urodynamic analysis of voiding dysfunction","volume":"17","author":"Sch\u00e4fer W","year":"1990","journal-title":"Urol Clin North Am"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20404"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06009.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.01.007"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0336-3"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20639"},{"key":"e_1_2_1_21_2","first-page":"1462","article-title":"Sur un syndrome de radiculo\u2010n\u00e9vrite avec hyperalbuminose du liquode c\u00e9phalo\u2010rachidien sans r\u00e9action cellulaire; remarques sur les caract\u00e9res cliniques et graphiques des r\u00e9flexes tendineux","volume":"40","author":"Guillain G","year":"1916","journal-title":"Bell M\u00e9m Soc M\u00e9d Paris"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1936.02260110060006"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1041579"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916939908993848"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1334"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/096777200301100412"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992280404300713"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb02435.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(71)90185-9"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2002.00099.x"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880171004"},{"key":"e_1_2_1_32_2","first-page":"17","article-title":"Neurologic and urodynamic characteristics of patients with Guillain\u2010Barr\u00e9 syndrome","volume":"111","author":"Gabavac Z","year":"1989","journal-title":"Lijec Vjesn"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.3.1245"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0022-5347(17)54668-6","article-title":"Urinary retention secondary to Landry\u2010Guillain\u2010Barr\u00e9 syndrome","volume":"126","author":"Kogan BA","year":"1981","journal-title":"J Urol"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)50709-0"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06588.x"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0768-0"},{"key":"e_1_2_1_38_2","first-page":"425","article-title":"The urodynamic evaluation of surgical outcome in patients with urinary retention due to central lumbar disc prolapse","volume":"21","author":"Yamanishi T","year":"2002","journal-title":"Neurourol Urodynam"},{"key":"e_1_2_1_39_2","first-page":"243","article-title":"Central motor conduction studies in patients with Guillain Barr\u00e9 syndrome","volume":"41","author":"Kalita J","year":"2001","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"e_1_2_1_40_2","first-page":"13","article-title":"A case of Guillain\u2010Barr\u00e9 syndrome complicated with severe autonomic failure and presented elevated anti\u2010GD1b and anti\u2010GQ1b antibody","volume":"42","author":"Inoue K","year":"2002","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_1_41_2","first-page":"878","article-title":"Autonomic involvement in Guillain\u2010Barr\u00e9 syndrome","volume":"46","author":"Kusunoki S","year":"2006","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.05.007"},{"key":"e_1_2_1_43_2","first-page":"287","article-title":"Micturitional disturbance in acute idiopathic autonomic neuropathy","volume":"75","author":"Sakakibara R","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20663","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T23:38:49Z","timestamp":1700523529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,3]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/nau.20663"],"URL":"https:\/\/doi.org\/10.1002\/nau.20663","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,3]]}}}