{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:37:54Z","timestamp":1772012274967,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T00:00:00Z","timestamp":1261094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Suprapontine lesions, such as those resulting from cerebrovascular disease, cause bladder storage dysfunction. Detrusor overactivity (DO) following cerebral infarction may be explained by impairment of the suprapontine regulatory system. However, precise mechanisms underlying DO is not clear. The following studies were undertaken to examine pharmacological and genetic mechanisms of DO in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p>Mechanisms of long\u2010lasting DO in rats with cerebral infarction require signal transfer, which begins with the opening of glutamate receptors at the dorsal pontine tegmentum. DO induced by cerebral infarction has been proven to be accompanied by an increase in <jats:italic>c\u2010fos<\/jats:italic> and zif268 expression in the dorsal pontine tegmentum and periaqueductal gray and mediated by the activation of <jats:italic>N<\/jats:italic>\u2010methyl\u2010D\u2010aspartate (NMDA) receptors, cyclooxygenase\u20102 (COX\u20102), and prostaglandin E synthase (PGES). Therefore, the arachidonic acid cascade is dynamically activated in the brain after brain ischemia. Bladder sensory pathways are potential targets for drugs used to treat various bladder dysfunctions because of their role in storage symptoms (i.e., urgency, frequency) and in triggering reflex bladder activity. Antimuscarinic drugs and \u03b1<jats:sub>1<\/jats:sub>\u2010blockers are the main treatments for overactive bladder, a condition caused by neurologic lesions, aging, bladder outlet obstruction, and other pathologies. These drugs affect sensory bladder storage symptoms, suggesting an action on bladder and urethral afferent pathways. Using animal models of DO, we demonstrated that these drugs improved bladder storage function via suppression of C\u2010fiber afferent nerves from the lower urinary tract. Neurourol. Urodynam. 29: 107\u2013111, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20746","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T19:15:54Z","timestamp":1261163754000},"page":"107-111","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacological and genetic analysis of mechanisms underlying detrusor overactivity in rats"],"prefix":"10.1002","volume":"29","author":[{"given":"Osamu","family":"Yokoyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(90)80048-R"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000296826.61499.26"},{"key":"e_1_2_1_4_2","volume-title":"Ministry of health","author":"Vital statistics","year":"2007"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.84"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.273.6.R1900"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63987-9"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000104861.73314.fe"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021179"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000052371.19582.5a"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65937-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000161601.77023.05"},{"key":"e_1_2_1_13_2","first-page":"649","article-title":"The role of prostaglandin E2 (PGE2) in cerebral infarction associated with detrusor overactivity. 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