{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:18:49Z","timestamp":1770347929342,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T00:00:00Z","timestamp":1253059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To clarify the effects of zolpidem, a \u03b3\u2010aminobutyric acid (GABA)<jats:sub>A<\/jats:sub>receptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading in Wistar rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CI was induced by left middle cerebral artery occlusion. The effects on bladder function of zolpidem alone or in combination with the GABA<jats:sub>A<\/jats:sub>receptor antagonist bicuculline, were then examined in the CI rats using cystometry. The antidiuretic effect of zolpidem was investigated in water\u2010loaded and Brattleboro rats (genetically vasopressin\u2010deficient). Blood samples were collected from water\u2010loaded rats to determine the aldosterone level 1 and 6\u2009hr after zolpidem administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Zolpidem increased bladder capacity dose\u2010dependently, but had no significant effect on bladder contraction pressure in CI rats. Bicuculline dose\u2010dependently inhibited zolpidem\u2010induced increases in bladder capacity without affecting bladder contraction pressure. Zolpidem dose\u2010dependently decreased the volume of urine excreted in water\u2010loaded and Brattleboro rats. Compared with the control group, zolpidem significantly increased the aldosterone concentration in the plasma of water\u2010loaded rats 1\u2009hr after administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Zolpidem increased bladder capacity via a GABAergic mechanism in CI rats, and suppressed urine excretion via a pathway that was not through activation of vasopressin V<jats:sub>2<\/jats:sub>receptors in water\u2010loaded and Brattleboro rats. These results suggest that zolpidem may improve nocturia via an increase in bladder capacity and a decrease in urine excretion. Neurourol. Urodynam. 29:587\u2013591, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.20797","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T19:38:11Z","timestamp":1253129891000},"page":"587-591","source":"Crossref","is-referenced-by-count":10,"title":["Zolpidem increases bladder capacity and decreases urine excretion in 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