{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:17:00Z","timestamp":1791091020681,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,9,21]],"date-time":"2009-09-21T00:00:00Z","timestamp":1253491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction &amp; Hypothesis<\/jats:title><jats:p>Determine if treatment of urge incontinence with tolterodine results in changes in bladder and\/or urethral sensation using Current Perception Threshold (CPT) testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with \u22651 incontinence episode on 7\u2010day diary were treated with 4 mg of long\u2010acting tolterodine for 2\u2010months. At baseline and 2\u2010months, participants had CPT testing of the urethral and bladder at 3 frequencies 2000, 250, and 5 Hz. Baseline and post\u2010treatment measures were compared using Wilcoxon Signed Rank Test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen women underwent baseline CPT testing. Four discontinued medication due to side effects and did not have repeated testing. Urethral CPT at 250 Hz was lower after treatment (median 1.3 [Interquartile range .69\u2010\u20102.1] and .75 [.45\u2010\u20101.2], p\u2009=\u2009.003) and at 5 Hz trended toward a significant decrease (1.1 [1\u2010\u20101.9] and .84 [.32\u2010\u20101.1], p\u2009=\u2009.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Urethral sensitivity improves after 2\u2010months of tolterodine, suggesting it may restore urethral sensory nerves in addition to known motor effects. Neurourol. 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