{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:07:55Z","timestamp":1793736475918,"version":"4.6.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T00:00:00Z","timestamp":1270684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore brain activity in the frontal micturition area during natural bladder behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five control subjects (one man and four women; mean age 61 years [38\u201370]) and four subjects with detrusor overactivity (all men; mean age 55 years [33\u201365]) were enrolled in the study. We performed real\u2010time measurements of oxyhemoglobin concentration (oxy\u2010Hb) changes in the frontal micturition area using functional near\u2010infrared spectroscopy (fNIRS) in response to quasi\u2010natural, continuous bladder filling, and voiding in a sitting position.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the control group the following results were obtained: (1) a slight increase of oxy\u2010Hb before first sensation occurred, (2) there was a continuous increase of oxy\u2010Hb during bladder filling to the point just after voiding began, (3) there was a continuous decrease of oxy\u2010Hb after voiding, (4) in subjects who were unable to urinate, oxy\u2010Hb also decreased after attempting to void, and (5) the area activated was the bilateral lateral prefrontal area, particularly Brodmann's areas 8, 10, and 46. In the detrusor overactivity group, (6) an increase of oxy\u2010Hb before first sensation was rare and frontal cortical activation was weak, (7) at the moment detrusor overactivity appeared, fNIRS brain activity in the frontal cortex did not change significantly; and otherwise the results were almost the same as those in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that the frontal micturition area is activated during natural bladder filling and voiding using fNIRS. Neurourol. Urodynam. 29:757\u2013764, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.20815","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T10:52:18Z","timestamp":1270723938000},"page":"757-764","source":"Crossref","is-referenced-by-count":32,"title":["Real\u2010time measurement of oxyhemoglobin concentration changes in the frontal micturition area: An fNIRS study"],"prefix":"10.1002","volume":"29","author":[{"given":"Ryuji","family":"Sakakibara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniko","family":"Tsunoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emina","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Yamanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Awa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/87.2.233"},{"key":"e_1_2_1_3_2","first-page":"553","article-title":"The cerebral control of micturition","volume":"58","author":"Andrew J","year":"1965","journal-title":"Proc R Soc Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00322-S"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199611250-00042"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.1.111"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.2.369"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06749.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.061"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(00)00095-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01550-0"},{"key":"e_1_2_1_13_2","volume-title":"Co\u2010planar stereotaxic atlas of the human brain: An approach to medical cerebral imaging","author":"Talairach J","year":"1988"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.4.781"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0286"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(05)66008-4"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.20815","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.20815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T16:58:42Z","timestamp":1700499522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.20815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/nau.20815"],"URL":"https:\/\/doi.org\/10.1002\/nau.20815","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717955933.793460854","asserted-by":"object"}]},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}